Patients with dermographism
and delayed pressure urticaria were more sensitive to omalizumab (13 out of 15 patients showed a complete response) than patients with cold and cholinergic urticaria (3/6 and 6/8 respectively showed a complete response).
Inhibiting effect of cetirizine on histamine-induced and 48/80-induced wheals and flares, experimental dermographism
, and cold-induced urticaria.
This is known as "black dermographism
," which translates literally to "black writing on the skin.
A positive reaction at the negative control site is associated with dermographism
, in which trauma to the skin causes wheals.
Most witnesses thought this unlikely; and it remains possible that they were psychosomatic, perhaps similar in process to the extraordinary dermographism
Following patients were excluded: patients on oral corticosteroids for past 1 month patients on oral anti-histamines for past 72 hours pregnant and lactating women patients with urticarial vasculitis patients with a history of type I hypersensitivity patients with physical urticaria other than simple dermographism
Physical urticaria generally occurs as a result of a physical stimulus and the most common form is dermographism.
Dermographism: Occurrence of eryhtema and swelling in a few minutes after the skin is marked with a solid object indicates presence of dermographism.