dermoepidermal junction

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der·mo·ep·i·der·mal in·ter·face

the interdigitating junction between the epidermis and the papillary layer of the dermis, where the dermal papillae fit into corresponding evaginations on the deep surface of the epidermis.

dermoepidermal junction

; DEJ undulating basement membrane zone between superficial (stratum papillare) and basal layer (stratum basale) of the epidermis


pertaining to the dermis and the epidermis.

dermoepidermal junction
is straight compared to the undulating border in humans; consists of lamina lucida externa, lamina densa, lamina lucida interna and anchoring filaments.
References in periodicals archive ?
We propose that ALM in situ should be considered a clinicopathologic entity: In a classic clinical picture of ALM (an irregularly shaped, darkly pigmented, flat lesion with diameter > 7 mm), pathologists should not hesitate in making such a diagnosis in the presence of a proliferation of single melanocytes along the dermoepidermal junction.
The melanocytes are disposed as single cells and as small nests with areas of confluent growth occurring over broad areas of the dermoepidermal junction (Figures 1, a and b, and 2, a).
Lentiginous melanomas do not show architectural alterations of the dermoepidermal junction, such as lamellar fibroplasia typical of dysplastic nevi.
Lentiginous melanoma is a rare subset of slowly progressing, radial growth phase melanoma characterized by lentiginous proliferation of moderately atypical epithelioid melanocytes showing focal pagetoid spread and nesting, associated with little architectural changes at the dermoepidermal junction.
According to Allen and Spitz, malignant melanocytes must be identified in the dermoepidermal junction or in the surface epithelium (ie, in situ component) to establish a diagnosis of primary malignant melanoma.