band-like lichenoid lymphocytic infiltrates with vacuolar changes at the dermoepidermal junction
Injury to the basal keratinocytes and other structures produce tiny vacuoles along the dermoepidermal junction
on both sides of the basal lamina known as vacuolar alteration or vacuolization.
The bandlike infiltrate obscuring the dermoepidermal junction
with cytoid body formation, confluent hyperkeratosis, irregular acanthosis, basal cell liquefactive degeneration, and apoptosis may closely mimic lichen planus.
Figure 2) The scalp biopsy reveaaed a scant superficial perivascular and periappendegeal lymphocytic infiltrate, also with focal areas of vacuolar alteration of the dermoepidermal junction
and melanophages in the papillary dermis.
To the side of the blister the epidermis showed scattered necrotic keratinocytes in mid-epidermis and at dermoepidermal junction
Primary histopathologic feature shows the presence of a diffuse infiltrate of histiocytes in the upper dermis with close apposition at the dermoepidermal junction
Histopathology showed similar findings as in the previous biopsy, but eosinophilic infiltrate was only present along the dermoepidermal junction
Importantly, when a biopsy of a clinically typical lesion of LP shows equivocal histopathology, a positive lupus band test along the dermoepidermal junction
supports a diagnosis of LP.
Histopathology results show epidermal atrophy, subepidermal separation, and haziness of the dermoepidermal junction
Histopathology of involved skin showed increase in number of melanocytes along with basal layer degeneration and mild infiltrate at dermoepidermal junction
There are also neutrophils and melanophages, indicative of repeat injury at the dermoepidermal junction
A cutaneous biopsy taken from an erythematous lesion on his hand showed vacuolization in the basal layer, perivascular infiltration of lymphoid cells in the dermoepidermal junction
and superficial zone, edema in the papillary dermis, and erythrocyte extravasation.