Biochemical studies on the patient indicated the accumulation of dermatan sulfate
in urine and also the decrease in activity of the enzyme [alpha]-L-iduronidase in leukocytes and peripheral blood dry drop.
Structural composition and anticoagulant activity of dermatan sulfate
from the skin of the electric eel, Electrophorus electricus (L).
Chondroitin/ dermatan sulfate
and heparin/heparan sulfate are synthesized on the common tetrasaccharide linker (GlcA[beta]1-3Gal[beta]1-3Gal[beta]1-4Xyl).
It is also referred to as dermatan sulfate
, and is made up of linear repeating units containing D-galactosamine and either L-iduronic acid or D-glucuronic acid.
Recently, Panagos, August, Jesson, and Uhrin (2016) reported that dermatan sulfate
(a class of SP obtained from animal tissue), using Fenton type free radical depolymerization, yielded exclusively oligosaccharides with reducing end acetylgalactosaminic acid.
MPS II is caused by accumulation of the glycosaminoglycans heparan sulfate and dermatan sulfate
, which occurs as a result of a deficiency of the lysosomal enzyme iduronate-2-sulfatase (IDS; EC 3.
Normal human urine contains mainly CS (-85-90% of the total), HS (-10-15%), and trace amounts of hyaluronic acid and dermatan sulfate
Due to the lack of standardization for algae, the study used animal glycosaminoglycans--chondroitin sulfate (CS), dermatan sulfate
(DS), heparan sulfate (HS) and heparin (HEP)--to characterize SPs obtained from algae with regard to standards and charge density.
C 8529; Sigma), and dermatan sulfate
from shark cartilage (cat.