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derivative chromosome

   Also found in: Wikipedia 0.01 sec.
derivative chromosome,
a chromosomal aberration caused by translocation.


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The 5' EWSR1 end of the probe remains on the derivative chromosome 22, whereas the 3' EWSR1 end of the probe moves to the derivative chromosome 12.
Clear cell sarcoma of tendons and aponeuroses: a review by Dim, Daniel C.; Cooley, Linda D.; Miranda, Roberto N. / Archives of Pathology & Laboratory Medicine
Significant advantages of our assay format include: 1) both derivative chromosomes are detected by separate fusion signals, 2) overall assay sensitivity is increased due to the complete absence of false positive cells, 3) assay accuracy is increased because probes are derived from regions outside of all known breakpoints, and 4) there is no reduction in actual signal intensity, since probes do not overlap any of the breakpoints.
Cancer Genetics Introduces Novel CML Fish Assay by Business Wire
Compared to conventional probes that identify only one derivative chromosome with a single fusion signal, our dual color, dual fusion probes detect very small numbers of tumor cells present in a population of normal cells, and do not generate false positive signals", Dr.
Cancer Genetics Awarded Phase II SBIR to Develop Novel Lymphoma Probes by Business Wire
 
 
 
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