derepression


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derepression

 [de″re-presh´un]
1. elevation of the level of an enzyme above the normal, either by lowering the corepressor concentration or by a mutation that decreases the formation of aporepressor or the response to the complete repressor.
2. the inhibition of the repressor substance produced by the regulator genes with the result that the operator gene is free to initiate the process of polypeptide formation.

de·re·pres·sion

(dē'rē-presh'ŭn),
A homeostatic mechanism for regulating enzyme production in an inducible enzyme system: an inducer, usually a substrate of a specific enzyme pathway, by combining with an active repressor (produced by a regulator gene) deactivates it; the release of the previously repressed operator is followed by enzyme production.

derepression

/de·re·pres·sion/ (de″re-presh´un) removal of repression, such as of an operon so that gene transcription occurs or is enhanced, with the net result frequently being elevation of the level of a specific enzyme.

de·re·pres·sion

(dē-rĕ-presh'ŭn)
A homeostatic mechanism for regulating enzyme production in an inducible enzyme system: an inducer, usually a substrate of a specific enzyme pathway, by combining with an active repressor (produced by a regulator gene) deactivates it.

derepression

switching on expression (see GENE EXPRESSION of genes that had been repressed (see REPRESSION).

derepression

1. elevation of the level of an enzyme above the normal, either by lowering the corepressor concentration or by a mutation that decreases the formation of aporepressor or the response to the complete repressor.
2. the inhibition of the repressor substance produced by the regulator genes with the result that the operator gene is free to initiate the process of polypeptide formation.
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References in periodicals archive ?
Regulus, in an alliance with GlaxoSmithKline, presented a poster titled "inhibition of microRNA function in macrophages by anti-miRs" demonstrating delivery of anti-miRs to macrophages and showed functional target engagement as measured by derepression of seed-matched transcripts.
2007, Suv4-20h deficiency results in telomere elongation and derepression of telomere recombination.
Derepression of BDNF transcription involves calcium-dependent phosphorylation of McCP2.
MEASURING THE CELLULAR ADENYLATE ENERGY CHARGE DURING THE DEREPRESSION OF THE PYRIMIDINE PATHWAY
Moreover, DNA hypomethylation in cancers is associated with chromosomal instability (23, 24), widespread derepression of ectopic gene expression (25), transcriptional activation of transposable elements (26), up-regulation of transcriptional noise (27), and an association with a more aggressive histologic type of cancer (28).