If enough receptors are activated, depolarization occurs and is maintained until the depolarizing agent
leaves the receptors.
2) Lethal injection involves the administration of three chemicals into the condemned inmate: thiopental sodium, a barbiturate anesthetic; pancuronium bromide, an agent that causes muscle paralysis including respiratory arrest; and potassium chloride, a depolarizing agent
intended to stop cardiac activity.
As mentioned previously, the only depolarizing agent on the market is succinylcholine (Anectine), which is an ultra short-acting agent that is typically only used for rapid intubation scenarios.
The depolarizing agents bind to acetylcholine receptors and cause a sustained postsynaptic membrane depolarization.
Then other semi synthetic non depolarizing agents
came in the market.
But the slow onset and inadequate intubating condition restrict the use of non-depolarizing agents
amongst the currently available non depolarizing agents
Rocuronium has the most rapid onset, intermediate duration of action minimal cardiovascular side effects and no histamine release.