depolarizing agent

depolarizing agent

Anesthesiology An agent–eg, succinylcholine, that depolarizes motor end plates, to maintain airways, control alveolar ventilation, abolish motor reflexes and relax muscle for surgery. See Succinylcholine. Cf Nondepolarizing agent.

depolarizing agent

a drug that causes depolarization. Usually applied to those used to produce neuromuscular block and muscle paralysis.
References in periodicals archive ?
If enough receptors are activated, depolarization occurs and is maintained until the depolarizing agent leaves the receptors.
2) Lethal injection involves the administration of three chemicals into the condemned inmate: thiopental sodium, a barbiturate anesthetic; pancuronium bromide, an agent that causes muscle paralysis including respiratory arrest; and potassium chloride, a depolarizing agent intended to stop cardiac activity.
As mentioned previously, the only depolarizing agent on the market is succinylcholine (Anectine), which is an ultra short-acting agent that is typically only used for rapid intubation scenarios.
The depolarizing agents bind to acetylcholine receptors and cause a sustained postsynaptic membrane depolarization.