depolarizing


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depolarizing

Capable of bringing about depolarization. Drugs that act at the junction between a nerve fibre and a muscle fibre to cause paralysis of the muscle (neuromuscular blocking agents) may be depolarizing or non-depolarizing. Depolarizing agents so affect the electrical charges at the interface that the nerve impulse can to be passed to the muscle fibre, but because the depolarization is maintained, the muscle, after the initial contraction, cannot continue to contract. Non-depolarizing agents such as curare act by combing with and blocking the nicotinic cholinergic receptors at the post-junctional membrane.
References in periodicals archive ?
y], relative to the depolarizing transient current density [J.
The decrease in spiking response was accompanied with a higher minimal depolarizing current required to evoke spikes (FA, 155 [+ or -] 21 pA; PM, 223 [+ or -] 23 pA; p = 0.
The ionic current responsible for depolarizing the membrane and propagating the action potential can travel through the cytoplasm or across the plasma membrane.
By preventing the binding of acetylcholine, the nondepolarizing agents block the depolarizing effects of acetylcholine, thereby preventing muscle contraction.
Changes in AP shape and duration result from alteration in the functional expression of depolarizing and repolarizing cur rents.
Brevetoxins are depolarizing substances that open voltage-gated sodium ion channels in cell membranes, leading to uncontrolled sodium influx into the cell (Baden 1983; Purkerson et al.
This condition may not be recognized until the patient is exposed to an anesthetic agent or depolarizing muscle relaxant, and such exposure may be catastrophic.
But at certain energies, called depolarizing resonances, the changes in spin direction become additive, throwing the spin orientation of such particles as protons out of alignment.
Adenocaine([R])'s polarizing patented formulation has shown superior myocardial protection and improved outcomes in preclinical studies and physicians are observing similar results during clinical use, in comparison to standard high potassium depolarizing cardioplegia.
We also validated that boosting extracellular calcium ion levels boosts seizure and migraine risk by 1) depolarizing nerve membranes, 2) increasing calcium channel mediated neurotransmitter release and 3) boosting muscle contractility," according to Mark Zamoyski, NexGen Biomedical, Inc.
A novel slow (<1 Hz) oscillation of neocortical neurons in vivo: depolarizing and hyperpolarizing components.
Response to nicotine is dose dependent, and increasing or toxic doses can produce a depolarizing blockade of receptors.