depolarizing


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depolarizing

Capable of bringing about depolarization. Drugs that act at the junction between a nerve fibre and a muscle fibre to cause paralysis of the muscle (neuromuscular blocking agents) may be depolarizing or non-depolarizing. Depolarizing agents so affect the electrical charges at the interface that the nerve impulse can to be passed to the muscle fibre, but because the depolarization is maintained, the muscle, after the initial contraction, cannot continue to contract. Non-depolarizing agents such as curare act by combing with and blocking the nicotinic cholinergic receptors at the post-junctional membrane.
References in periodicals archive ?
Malignant hyperthermia (MH) is an inherited autosomal life threatening skeletal muscle disorder usually triggered by certain drugs of general anesthesia like volatile anesthetics and depolarizing muscle relaxants (succinylcholine)1.
Then other semi synthetic non depolarizing agents came in the market.
Immediately after each pre-conditioning pulse, a depolarizing test pulse at 50 mV (500 ms) was applied.
In response to a depolarizing step current density [J.
Succinylcholine, the only depolarizing muscle relaxing agent in clinical use, is well-known for its most rapid onset of action and short duration of action2,8,9 compared to the NDMR dugs.
Action potential duration lengthening and consequently prolonged repolarization cause early after depolarizations (EADs) due to activation or delayed inactivation of inward depolarizing sodium and L type calcium currents.
Water-borne memories of stored toxins, electromagnetic or modern-day electropollutants such as Wi-Fi frequencies, unstable chlorination or fluoridation compounds, or the unstable sodium of water softeners challenge homeostasis with life-restricting, depolarizing, and frequency-scrambling information.
This review is important because it allows identification of a scalar field contribution that was not considered in the method of derivation but influences the uniqueness of the field recovery process, and it reveals an expected and unexpected depolarizing dyad contribution.
From the sinus node, the depolarization wave, rounding the SVC, passes to the right atrium (RA); first, it activates the upper part of the appendage, and then the front spreads evenly, depolarizing the middle and lower parts of the RA appendage on the ventral side.
If enough receptors are activated, depolarization occurs and is maintained until the depolarizing agent leaves the receptors.
It is a condition triggered by halogenated anesthetic gasses and succinylcholine, a depolarizing muscle relaxant.