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depigmentation

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de·pig·men·ta·tion (d-pgmn-tshn, -mn-)
n.
The loss or removal of normal pigmentation.

depigmentation
removal of pigment; usually refers to melanin. See also hypopigmentation.

nasal depigmentation
occurs in dogs with a normal, darkly pigmented nasal planum at birth which later fades to brown or a pale gray-white. Called also Dudley nose, the cause is unknown, but it may be a form of vitiligo. A seasonal loss of pigmentation, usually during winter months, occurs in some breeds, including Siberian huskies, Golden retrievers, Labrador retrievers and Bernese mountain dogs. Called also snow nose.
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Depigmentation (Dudley Nose).

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The main clinical manifestations of the exposed subjects were similar to those found in other arsenic poisoning areas of the world (2,3,33), mainly including cutaneous depigmentation, hyperpigmentation, and hyperkeratosis and increased incidence of peripheral vascular disorder, peripheral neuropathy, and liver swelling (30,31).
Didanosine is associated with the following side effects: pancreatitis, peripheral neuropathy, vision changes (retinal depigmentation or optic neuritis), nausea and diarrhea.
Vitiligo is a disease of the pigment producing cells characterized by patchy depigmentation of the skin of the face and hands.
 
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