deoxypyridinoline


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deoxypyridinoline

Bone disease A crosslink of type I collagen present in bone which is excreted unmetabolized in urine and is a specific marker of bone resorption, and ↑ in Pts with osteoporosis. See Osteoporosis, Pyrilinks-D®.

deoxypyridinoline

(dē-ŏk″sē-pĭ-rĭ-dĭn′ō-lēn, -lĭn),

Dpd

A component of the structural matrix of bone, principally found in type 1 collagen as a structural cross link. It provides tensile strength to bone.

When bone resorption exceeds bone rebuilding (for example, in osteoporosis), Dpd is released into the circulation and excreted unchanged in the urine. The detection of elevated levels of Dpd in a concentrated urine specimen is used as a marker of ongoing bone loss in osteoporosis. Reduced levels of Dpd are an indicator of the effectiveness of therapies that reduce bone resorption (e.g., bisphosphonates).

The Dpd urine test is performed by obtaining the first urine voided by a patient on awakening—this ensures that the specimen will be maximally concentrated. The level of Dpd obtained is expressed in nmol of Dpd/mmol of urinary creatinine.

References in periodicals archive ?
As a result, PE significantly inhibited the increased urinary Ca excretion and activity of bone resorption markers including tartrate-resistant acid phosphatase (TRAP), deoxypyridinoline crosslinks and cathepsin K in OVX rats, whereas exhibited little effects on the body, uterus and vagina weight.
The immunoassay claims are directed to assays for measuring bone resorption by contacting an unhydrolyzed urine sample with an antibody that binds to free deoxypyridinoline cross-links, detecting any binding of the antibody in the body fluid sample, and correlating the detected binding to bone resorption in vivo.
Long-term treatment of osteoporosis with FOSAMAX 10 mg/day (for up to five years) reduced urinary excretion of markers of bone resorption, deoxypyridinoline and cross-linked N-telopeptides of type l collagen, by approximately 50% and 70%, respectively, to reach levels similar to those seen in healthy premenopausal women.
Treament of immunized mice with icariin (25 mg/kg/day) reduced urinary deoxypyridinoline concentrations -25% (p < 0.
Urinary deoxypyridinoline is a usefu) biochemical bone marker for the management of postmenopausal osteoporosis.
12) The investigators divided the patients by baseline urine deoxypyridinoline levels below and above the median value.
After multivariate adjustment, BMD, parathyroid hormone, and urinary deoxypyridinoline (U-DPD) were adversely associated with concentrations of urinary cadmium (p < 0.
It will be important to document that the amino-terminal peptide of collagen cross-links (NTX), pyridinoline (PYD), or deoxypyridinoline (DPD) perform as well when subjected to such rigorous study.
Urine and serum samples were assayed for three markers [osteocalcin (OC), bone alkaline phosphate (BAP), and deoxypyridinoline (DPD)] at baseline and again at 3-month intervals for 2 years.
Soy consumption was associated with increases of up to 18% in bone-specific alkaline phosphatase, 21% in deoxypyridinoline, and 34% in osteocalcin.
Pyridinoline (pyr) and deoxypyridinoline (dpyr) are the two nonreducible pyridinium cross-links present in the mature form of collagen.
17) reported that among markers of bone turnover, BALP osteocalcin, and CTx and NTx (N-and C-terminal collagen cross-links) levels were within normal limits whereas urinary deoxypyridinoline levels were increased.