Increasing urinary cadmium, but not serum retinol, was associated with increases in deoxypyridinoline
and decreases in parathyroid hormone concentrations, which indicates the effect of cadmium on bone turnover and increased bone resorption.
Two bone markers were measured: bone-specific alkaline phosphatase (BSAP) and deoxypyridinoline
Markers of bone turnover include bone-specific alkaline phosphatase, osteocalcin, and the collagen cross-links, deoxypyridinoline
, C-telopeptide (CTX), and N-telopeptide (NTX).
Assessment and recommendations of factors contributing to preanalytical variability of urinary pyridinoline and deoxypyridinoline
How it works: It tests for the presence of a bone breakdown product in the urine called Deoxypyridinoline
Patent Office has allowed two of its 1987 patent applications for deoxypyridinoline
(D-Pyr) bone resorption assays.
However these markers, which were widely used at the outset of this study, have now been superseded by more sensitive and specific assays such as urinary deoxypyridinoline
Daily oral doses of alendronate (5, 20, and 40 mg for six weeks) in postmenopausal women produced biochemical changes indicative of dose-dependent inhibition of bone resorption, including decreases in urinary calcium and urinary markers of bone collagen degradation (such as deoxypyridinoline
and cross-linked N-telopeptides of type I collagen).
As a result, PE significantly inhibited the increased urinary Ca excretion and activity of bone resorption markers including tartrate-resistant acid phosphatase (TRAP), deoxypyridinoline
crosslinks and cathepsin K in OVX rats, whereas exhibited little effects on the body, uterus and vagina weight.
Commercially available kits were used (Biosource, LINCO Research) to measure TNF-[alpha], IL10, IL6, adiponectine, osteocalcin and urine deoxypyridinoline
as it has been known that all kits have already completed inter- and intra-assay CV values.
Serum B2-microglubulin concentration correlates with urinary concentrations of type | collagen cross-linked N-telopeptides and deoxypyridinoline
in rheumatoid arthritis.
Serum osteocalcin level was low (68%) and urinary deoxypyridinoline
to creatinine ratio was high (79%), which demonstrated low bone formation with high resorption.