As a result, PE significantly inhibited the increased urinary Ca excretion and activity of bone resorption markers including tartrate-resistant acid phosphatase (TRAP), deoxypyridinoline
crosslinks and cathepsin K in OVX rats, whereas exhibited little effects on the body, uterus and vagina weight.
The immunoassay claims are directed to assays for measuring bone resorption by contacting an unhydrolyzed urine sample with an antibody that binds to free deoxypyridinoline
cross-links, detecting any binding of the antibody in the body fluid sample, and correlating the detected binding to bone resorption in vivo.
Long-term treatment of osteoporosis with FOSAMAX 10 mg/day (for up to five years) reduced urinary excretion of markers of bone resorption, deoxypyridinoline
and cross-linked N-telopeptides of type l collagen, by approximately 50% and 70%, respectively, to reach levels similar to those seen in healthy premenopausal women.
Treament of immunized mice with icariin (25 mg/kg/day) reduced urinary deoxypyridinoline
concentrations -25% (p < 0.
is a usefu) biochemical bone marker for the management of postmenopausal osteoporosis.
12) The investigators divided the patients by baseline urine deoxypyridinoline
levels below and above the median value.
After multivariate adjustment, BMD, parathyroid hormone, and urinary deoxypyridinoline
(U-DPD) were adversely associated with concentrations of urinary cadmium (p < 0.
It will be important to document that the amino-terminal peptide of collagen cross-links (NTX), pyridinoline (PYD), or deoxypyridinoline
(DPD) perform as well when subjected to such rigorous study.
Urine and serum samples were assayed for three markers [osteocalcin (OC), bone alkaline phosphate (BAP), and deoxypyridinoline
(DPD)] at baseline and again at 3-month intervals for 2 years.
Soy consumption was associated with increases of up to 18% in bone-specific alkaline phosphatase, 21% in deoxypyridinoline
, and 34% in osteocalcin.
Pyridinoline (pyr) and deoxypyridinoline
(dpyr) are the two nonreducible pyridinium cross-links present in the mature form of collagen.
17) reported that among markers of bone turnover, BALP osteocalcin, and CTx and NTx (N-and C-terminal collagen cross-links) levels were within normal limits whereas urinary deoxypyridinoline
levels were increased.