deoxycorticosterone

Also found in: Dictionary, Acronyms, Encyclopedia, Wikipedia.

Related to deoxycorticosterone: Desoxycorticosterone

desoxycorticosterone

[des-ok″sĭ-kor″tĭ-ko-stēr´ōn]

a mineralocorticoid with no glucocorticoid activity, secreted in small amounts by the human adrenal cortex. It is used with a glucocorticoid for replacement therapy in adrenocortical insufficiency and addison's disease and for treatment of salt-losing adrenogenital syndrome.

de·ox·y·cor·ti·cos·ter·one (DOC),

(dē-oks'ē-kōr'ti-kos'tĕr-ōn),

An adrenocortical steroid, principally a biosynthetic precursor of corticosterone, which occasionally appears in adrenocortical secretions; a potent mineralocorticoid with no appreciable glucocorticoid activity.

Synonym(s): 21-hydroxyprogesterone, cortexone, deoxycortone, desoxycortone

deoxycorticosterone

(dē-ŏk′sē-kôr′tĭ-kŏs′tə-rōn′)

A steroid hormone, C₂₁H₃₀O₃, secreted by the adrenal cortex or produced synthetically and formerly used to treat adrenal insufficiency.

deoxycorticosterone

Endocrinology An adrenal steroid with potent mineralocorticoid properties, and minimal glucocorticosteroid properties ↑ in Congenital adrenal hyperplasia, Cushing syndrome, primary aldosteronism, low renin HTN, adrenal CA ↓ in Adrenal insufficiency or hypoplasia

de·ox·y·cor·ti·co·ster·one

(dē-oks'ē-kōr-ti-kos'tĕr-ōn)

An adrenocortical steroid, principally a biosynthetic precursor of corticosterone and possibly aldosterone, which rarely appears in adrenocortical secretions; a potent mineralocorticoid with no appreciable glucocorticoid activity.
Compare: bioregulator
Synonym(s): 21-hydroxyprogesterone.

de·ox·y·cor·ti·co·ster·one

(dē-oks'ē-kōr-ti-kos'tĕr-ōn)

Potent mineralocorticoid with no appreciable glucocorticoid activity.

11-desoxycorticosterone, deoxycorticosterone, deoxycortone

one of the mineralocorticoids, adrenocortical steroids which lack a substituent at C-11; has a greater effect on electrolyte metabolism than glucocorticoids. Available pharmaceutically as the acetate (DOCA), which is short-acting, and the pivalate (DOCP), a slow release form for use in the treatment of hypoadrenocorticism.

Mentioned in ?

References in periodicals archive ?

1975) Enzymatic studies on adrenocortical deoxycorticosterone 11[beta]-hydroxylase system.

1947) Cytochemical evidence for the cessation of hormone production in the zona glomerulosa of the rat's adrenal cortex after prolonged treatment with deoxycorticosterone acetate.

Functional zonation of the rat adrenal cortex: the development and maintenance

In 11 (beta) OHD deficiency, 11 deoxycorticosterone level is raised whereas in 3 (beta) HSD deficiency, serum 17 (alpha) hydoxypregnenolone and DHEAS are raised.

Classic congenital adrenal hyperplasia: A delayed presentation

Both in the first and second week following recovery, all animals received deoxycorticosterone acetate (15 mg/animal, s.

It was demonstrated that long-term exposure of uninephrec-tomized rats to deoxycorticosterone acetate (DOCA/Salt) induces sympathoexitation, cardiac fibrosis and hypertrophy by several mechanism (Fujisawa et al.

Antihypertensive effect of nuatigenin-3-O-[beta]-chacotriose from Solanum sisymbriifolium Lam. (Solanaceae) (nuati pyta) in experimentally hypertensive (ARH + DOCA) rats under chronic administration

Conditions mimicking mineralocorticoid excess (with low-renin hypertension due to sodium retention, and hypokalemia) but with low aldosterone concentrations (unlike in PAL) include licorice overuse, which results in inhibition of 11[beta]-hydroxysteroid dehydrogenase type 2 (11[beta]-HSD2); congenital 11[beta]-HSD2 deficiency; Liddle syndrome (constitutive activation of the epithelial sodium channel); and conditions associated with adrenocorticotropic hormone excess (causing high deoxycorticosterone concentrations), including ectopic adrenocorticotropic hormone syndrome, congenital adrenal hyperplasia due to 11[beta]-hydroxylase or 17[alpha]-hydroxylase deficiency, and glucocorticoid resistance syndrome (2).

Too much of a good thing: a woman with hypertension and hypokalemia

Effect of chronic treatment with two different ET (A) selective endothelial receptor antagonists on blood pressure and small artery structure of deoxycorticosterone acetate (DOCA)-salt hypertensive rats.

El efecto de nefroproteccion de los calcio-antagonistas: una contribucion al conocimiento de su probable mecanismo

Liquorice and glycyrrhetinic acid increase DHEA and deoxycorticosterone levels in vivo and in vitro by inhibiting adrenal SULT2A1 activity.

Not skin deep: Psoriatic arthritis and the complications of systemic inflammation seen with psoriasis

05% to ouabain and dihydroouabain: pregnenolone, corticosterone, progesterone, deoxycorticosterone, aldosterone, cortisone, hydroxyprogesterone, uracil.

Human adrenal cells in culture produce both ouabain-like and dihydroouabain-like factors

Steroid protein conjugates: preparation and characterization of conjugates of bovine serum albumin with progesterone, deoxycorticosterone and estrone.

Radioimmunoassay of cortisone in serum, urine, and saliva to assess the status of the cortisol-cortisone shuttle