deoxycorticosterone


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Related to deoxycorticosterone: Desoxycorticosterone

desoxycorticosterone

 [des-ok″sĭ-kor″tĭ-ko-stēr´ōn]
a mineralocorticoid with no glucocorticoid activity, secreted in small amounts by the human adrenal cortex. It is used with a glucocorticoid for replacement therapy in adrenocortical insufficiency and addison's disease and for treatment of salt-losing adrenogenital syndrome.

de·ox·y·cor·ti·cos·ter·one (DOC),

(dē-oks'ē-kōr'ti-kos'tĕr-ōn),
An adrenocortical steroid, principally a biosynthetic precursor of corticosterone, which occasionally appears in adrenocortical secretions; a potent mineralocorticoid with no appreciable glucocorticoid activity.
Synonym(s): 21-hydroxyprogesterone, cortexone, deoxycortone, desoxycortone

deoxycorticosterone

(dē-ŏk′sē-kôr′tĭ-kŏs′tə-rōn′)
n.
A steroid hormone, C21H30O3, secreted by the adrenal cortex or produced synthetically and formerly used to treat adrenal insufficiency.

deoxycorticosterone

Endocrinology An adrenal steroid with potent mineralocorticoid properties, and minimal glucocorticosteroid properties ↑ in Congenital adrenal hyperplasia, Cushing syndrome, primary aldosteronism, low renin HTN, adrenal CA ↓ in Adrenal insufficiency or hypoplasia

de·ox·y·cor·ti·co·ster·one

(dē-oks'ē-kōr-ti-kos'tĕr-ōn)
An adrenocortical steroid, principally a biosynthetic precursor of corticosterone and possibly aldosterone, which rarely appears in adrenocortical secretions; a potent mineralocorticoid with no appreciable glucocorticoid activity.
Compare: bioregulator
Synonym(s): 21-hydroxyprogesterone.

de·ox·y·cor·ti·co·ster·one

(dē-oks'ē-kōr-ti-kos'tĕr-ōn)
Potent mineralocorticoid with no appreciable glucocorticoid activity.

11-desoxycorticosterone, deoxycorticosterone, deoxycortone

one of the mineralocorticoids, adrenocortical steroids which lack a substituent at C-11; has a greater effect on electrolyte metabolism than glucocorticoids. Available pharmaceutically as the acetate (DOCA), which is short-acting, and the pivalate (DOCP), a slow release form for use in the treatment of hypoadrenocorticism.
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References in periodicals archive ?
Deoxycorticosterone acetate/salt rats: hypertension and sympathoexitation driven by increase NaCI levels.
Antihypertensive effect of nuatigenin-3-O-[beta]-chacotriose from Solanum sisymbriifolium Lam. (Solanaceae) (nuati pyta) in experimentally hypertensive (ARH + DOCA) rats under chronic administration
Steroid concentrations in the medium and cell lysate were measured using liquid chromatography/mass spectrometry for 12 steroids [pregnenolone (PREG), 17[alpha]-hydroxypregnenolone (HPREG), dehy-droepiandrosterone (DHEA), progesterone (PROG), 17[alpha]-hydroxyprogesterone (HPROG), androstenedione (DIONE), testosterone (T), deoxycorticosterone (DCORTICO), corticos-terone (CORTICO), ALDO, 11-deoxycortisol (DCORT), and CORT] and using enzyme-linked immunosorbent assay for two additional steroids [estrone ([E.
Computational model of steroidogenesis in human H295R cells to predict biochemical response to endocrine-active chemicals: model development for metyrapone
Conditions mimicking mineralocorticoid excess (with low-renin hypertension due to sodium retention, and hypokalemia) but with low aldosterone concentrations (unlike in PAL) include licorice overuse, which results in inhibition of 11[beta]-hydroxysteroid dehydrogenase type 2 (11[beta]-HSD2); congenital 11[beta]-HSD2 deficiency; Liddle syndrome (constitutive activation of the epithelial sodium channel); and conditions associated with adrenocorticotropic hormone excess (causing high deoxycorticosterone concentrations), including ectopic adrenocorticotropic hormone syndrome, congenital adrenal hyperplasia due to 11[beta]-hydroxylase or 17[alpha]-hydroxylase deficiency, and glucocorticoid resistance syndrome (2).
Too much of a good thing: a woman with hypertension and hypokalemia

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