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deoxyadenosine |
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| In the disease, the lack of ADA enzyme allows the buildup of 2' deoxyadenosine triphosphate, a chemical that is particularly detrimental to immune system cells, especially T cells. The study authors concluded that "clofarabine is the first deoxyadenosine analog with promising activity in pediatric ALL, pediatric AML and adult acute leukaemia at doses that are well tolerated. |
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