dense granule


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dense granule

Cardiology
A specialised spherical storage and secretory vesicle in platelets which contains ADP, ATP, ionised calcium, pyrophosphate and serotonin. Reduced-platelet dense-granule secretion is associated with marked protection against arterial thrombosis, inflammation, and neointimal hyperplasia after vascular injury in a mouse model.

Pathology
Dense-core granules, see there.
References in periodicals archive ?
Hermansky-Pudlak syndrome (HPS) is an autosomal recessive disorder caused by mutations in one of ten different genes that lead to platelet dense granule deficiency.
Dense granule storage pool disorders (SPDs) have decreased aggregation with ADP, adrenaline and collagen and often occur in association with other hereditary disorders.
Numerous studies showed immunogenicity and protective efficacy of dense granule (GRA) antigens (9).
Their topics include the dense granule proteins of Toxoplasma gondii, new insights into the liver stage biology of malaria parasites, multi-locus sequence typing (MLST) and its applications in epidemiological studies for parasitic infections, the metabolism of poly-ADP-ribose in trypanosomatids, parasite control and livestock production in Nigeria, possible impacts of climate change on waterborne parasitic infections at northern latitudes, and the diagnosis of opportunistic parasites in liver transplantation.
12 The instrument, available from Chrono-log Corporation (Havertown PA) records aggregation and secretion of dense granule adenosine triphosphate (ATP).
37,38) Whole blood platelet aggregation can be combined with studies of dense granule adenosine triphosphate release with a lumiaggregometer.
Dense granule defects can also be studied by lumiaggregometry, where ATP released from dense granules is measured by a firefly luciferin-luciferase reagent simultaneously with aggregation.
Numerous studies have shown that the recombinant production of several toxoplasma antigens, including dense granule antigens (GRAS) has a great potential as diagnostic reagents.
A variety of genetic abnormalities lead to dense granule (dense body, [delta]-granule) deficiency, most associated with albinism, where the number of dense granules is reduced.
Plateiet aggregation studies from patients with dense granule storage pool disorders often show a primary wave of aggregation but an absent or decreased secondary wave.
Heterogenous abnormalities of platelet dense granule ultrastructure in 20 patients with congenital storage pool deficiency.