dense granule


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dense granule

Cardiology
A specialised spherical storage and secretory vesicle in platelets which contains ADP, ATP, ionised calcium, pyrophosphate and serotonin. Reduced-platelet dense-granule secretion is associated with marked protection against arterial thrombosis, inflammation, and neointimal hyperplasia after vascular injury in a mouse model.

Pathology
Dense-core granules, see there.
References in periodicals archive ?
Dense granule defects can also be studied by lumiaggregometry, where ATP released from dense granules is measured by a firefly luciferin-luciferase reagent simultaneously with aggregation.
Their topics include the dense granule proteins of Toxoplasma gondii, new insights into the liver stage biology of malaria parasites, multi-locus sequence typing (MLST) and its applications in epidemiological studies for parasitic infections, the metabolism of poly-ADP-ribose in trypanosomatids, parasite control and livestock production in Nigeria, possible impacts of climate change on waterborne parasitic infections at northern latitudes, and the diagnosis of opportunistic parasites in liver transplantation.
12 The instrument, available from Chrono-log Corporation (Havertown PA) records aggregation and secretion of dense granule adenosine triphosphate (ATP).
37,38) Whole blood platelet aggregation can be combined with studies of dense granule adenosine triphosphate release with a lumiaggregometer.
Plateiet aggregation studies from patients with dense granule storage pool disorders often show a primary wave of aggregation but an absent or decreased secondary wave.
A variety of genetic abnormalities lead to dense granule (dense body, [delta]-granule) deficiency, most associated with albinism, where the number of dense granules is reduced.
Heterogenous abnormalities of platelet dense granule ultrastructure in 20 patients with congenital storage pool deficiency.
During invasion and creation of the PV membrane, apically oriented organelles called micronemes and rhoptries are discharged, followed later by release of dense granules content (DG).
The commonly reported mechanisms are decreased life span of platelets due to immunological and non-immunological mechanisms, elevated macrophage colony stimulating factors causing platelet destruction; ultra structural changes like centralization of dense granules, glycogen depletion, formation of pseudopods, and micro aggregation; consumption by diffused intravascular coagulation (DIC) host oxidative stress through oxidization of membrane lipids causing changes in fluidity and permeability of the cell membrane and its effect on fragility (2,3).
Many degenerating and nondegenerated gonadotropes, somatotropes, and lactotropes showed dilated ER (Figures 3 and 5) and hypertrophic Golgi areas, occasionally with some lightly dense granules inside.