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dense deposit disease

   Also found in: Wikipedia 0.01 sec.
dense deposit disease
Type II membranoproliferative glomerulonephritis Nephrology A glomerulopathy in which electron-dense material–usually complement C3 is deposited in the glomerular capillary basement membrane, with ↓ serum C3, due to alternate complement pathway activation, in the face of normal C4; there is patchy mesangial proliferation in Bowman's capsule, and accumulation of basement membrane material in the peritubular capillaries and arterioles Prognosis Poor. See Tramtrack appearance.


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Investigators will present two case reports of patients with aHUS treated with Soliris and a separate case report regarding a patient with a second rare kidney disorder, dense deposit disease, treated with Soliris.
Clinical studies are being initiated in patients with two other ultra-rare, severe complement-inhibitor deficiency diseases: atypical hemolytic uremic syndrome (aHUS) and dense deposit disease, two diseases in which the lack of naturally occurring complement inhibitors can cause life-threatening kidney damage.
Clinical studies are being initiated in patients with two other rare, severe complement-inhibitor deficiency diseases: atypical hemolytic uremic syndrome (aHUS) and dense deposit disease, two diseases in which the lack of naturally occurring complement inhibitors can cause life-threatening kidney damage.
 
 
 
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