dendritic spines


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den·drit·ic spines

variably long excrescences of nerve cell dendrites, varying in shape from small knobs to thornlike or filamentous processes, usually more numerous on distal dendrite arborizations than on the proximal part of dendritic trunks. Dentritic spines are a preferential site of synaptic axodendritic contact; they are sparse or absent in some types of nerve cells (motor neurons, the large cells of the globus pallidus, and stellate cells of the cerebral cortex), and exceedingly numerous in others such as the pyramidal cells of the cerebral cortex and the Purkinje cells of the cerebellar cortex.
Synonym(s): dendritic thorns, gemmule (2)

den·drit·ic spines

(den-drit'ik spīnz)
Variably long excrescences of nerve cell dendrites, varying in shape from small knobs to thornlike or filamentous processes, usually more numerous on distal dendrite arborizations than on the proximal part of dendritic trunks; they are a preferential site of synaptic axodendritic contact; sparse or absent in some types of nerve cells (motor neurons, the large cells of the globus pallidus, stellate cells of the cerebral cortex), exceedingly numerous in others such as the pyramidal cells of the cerebral cortex and the Purkinje cells of the cerebellar cortex.
Synonym(s): gemmule (2) .
References in periodicals archive ?
Dendritic spines biochemistry, modeling and properties.
Our findings support the growing theory that Alzheimer's disease memory deficits may result from loss of dendritic spines and that this process is mediated by amyloid-beta protein.
They reported that the brain from a 4-month-old infant with FAS showed a significant decrease in the number of dendritic spines on nerve cells projecting from the cortex to other parts of the brain and spinal cord.
TEHRAN (FNA)- Researchers showed for the first time that sleep after learning encourages the growth of dendritic spines, the tiny protrusions from brain cells that connect to other brain cells and facilitate the passage of information across synapses, the junctions at which brain cells meet.
Researchers at NYU Langone Medical Center have shown for the first time that sleep after learning encourages the growth of dendritic spines, the tiny protrusions from brain cells that connect to other brain cells and facilitate the passage of information across synapses, the junctions at which brain cells meet.
The researchers used a microscope that allowed them to peer directly into nerve cells within the brains of living mice, and within two hours of giving a drug they found significant increases in the density of dendritic spines structures that bear synapses required for signaling in the animals frontal cortex.
Dendritic spines are essential for nerve-to-nerve communication; throughout life they continue to morph, grow and perish.
The technology quantifies and characterizes the morphology and maturity of synaptic dendritic spines, which are fundamental to information processing in the brain.
Dendritic spines help transmit electrical signals to the neuron's cell body.
Dendritic spines are hair-like protrusions that brain cells use to communicate with one another.
2005), and the increased size of dendritic spines (Korkotian and Segal 1999).
Craft said, "If insulin were administered before the oligomeric Abeta, the dendritic spines were protected.