Our work suggests that APP balance is critical for normal neuronal development, connection of synapses, and dendritic spine
development, all of which have implications for the extensive synapse loss and cognitive decline seen in Alzheimer's disease," said the study's author, Dr Hyang-Sook Hoe, a research scientist in the department of neuroscience.
To determine how DISC1 regulates dendritic spine
formation, the researchers studied which brain proteins interact with the protein expressed by the DISC1 gene.
The team now wants to further identify the key molecules involved in the dendritic spine
production and target them in the same way as the oestrogen receptor in order to ultimately be able to treat schizophrenia and other mental disorders.
Previous reports, in which changes in spinophilin and RC3/neurogranin expression were found to correlate with changes in dendritic spine
density or dendritic arborization (Law et al.
Comparing the methods for quantitative analysis of dendritic spine
The scientists found that the sleep-deprived mice experienced significantly less dendritic spine
growth than the well-rested mice.
The spines play a pivotal role in memory formation and learning, and specific changes in dendritic spine
size and shape have been implicated in brain disorders including schizophrenia and Alzheimer's disease.
We recognize that Afraxis is a global leader in dendritic spine
analysis which provides a sophisticated and quantifiable read-out on neuroprotection.
Prior to his appointment as chief scientific officer, he was a principle investigator and director of R&D strategy for Afraxis Holdings from 2010-2013 during which time he developed the foundations of the ESP program to rapidly evaluate drug impact on the hallmark dendritic spine
abnormalities in the Fmr1-knockout mouse model of Fragile-X Syndrome.
In this multidisciplinary project, I will combine state-of-the-art genetic, biochemical and imaging techniques to study the role of astrocytes in mediating dendritic spine
With a variety of tests on mice, the scientists showed that amyloid beta oligomers can't cause this dendritic spine
loss unless AMPK overactivation occurs-and indeed AMPK overactivation on its own can cause the spine loss.
In addition to its impact on dendritic spine
biology, PAK is also implicated in cancer, including Neurofibromatosis, a rare form of cancer for which there are no approved drugs.