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dendritic spine |
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In this article we show that treatment of ovariectomized rats with BPA dose-dependently inhibits the estrogen-induced formation of dendritic spine synapses on pyramidal neurons in the CA1 area of the hippocampus. When a female is ovulating, the estrogen level is high and the apical dendritic spines in the hippocampus, treelike projections that make connections with other neurons, increase in number and length. The ghrelin-deficient animals had about 25 percent fewer dendritic spines than normal mice did. |
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