dendritic cell vaccine


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dendritic cell vaccine

An anticancer vaccine made by extracting dendritic (antigen-presenting) cells from a patient with cancer, stimulating those cells to reproduce themselves, and then exposing them to antigens taken from the patient's cancer. The antigenically exposed dendritic cells are then injected back into the patient.
See also: vaccine
References in periodicals archive ?
Dendritic cell vaccines provide another form of therapy for conditions that cannot be addressed with chemotherapy or radiation, such as metastatic renal cancer or malignant melanoma.
We have filed an Investigational New Drug (IND) application for ICT-140, a dendritic cell vaccine targeting ovarian cancer antigens and cancer stem cells at the end of 2012.
We are planning to initiate a 20-patient, investigator-sponsored Phase I trial of ICT-121, a dendritic cell vaccine targeting CD133, in patients with recurrent glioblastoma, also before the end of 2012.
Rosenthal will introduce the LEAPS dendritic cell vaccine approach as a potentially new personalized immunotherapy for chronic viral infections and tumors at the Cancer Vaccine Meeting in Cambridge, Mass.
Geron Corporation (Nasdaq:GERN) today announced the presentation of interim data from its phase II trial of GRNVAC1, an autologous dendritic cell vaccine targeting telomerase, in patients with acute myelogenous leukemia (AML) at the 51st Annual Meeting of the American Society of Hematology (ASH) in New Orleans, Louisiana.
A phase II randomized clinical trial enrolling patients with newly diagnosed GBM will explore whether dendritic cell vaccines targeting the human CMV antigen pp65 expressed as fusion protein with LAMP improves survival.
These take several forms including peptide vaccines and dendritic cell vaccines that are administered along with another agent to boost the immune response to the vaccine.
In order to make dendritic cell vaccines some of the patient's dendritic cells are extracted and immune cell stimulants are used to reproduce large amounts of dendritic cells in the lab.
The company is focusing on development of its dendritic cell vaccines.
If the melanoma trial is successful, ML will be seeking partners interested in using the technology to develop dendritic cell vaccines for a range of life threatening diseases.