denature(redirected from denaturations)
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tr.v. dena·tured, dena·turing, dena·tures
1. To change the nature or natural qualities of.
2. To render unfit to eat or drink without destroying usefulness in other applications, especially to add methanol to (ethyl alcohol).
a. To cause the tertiary structure of (a protein) to unfold, as with heat, alkali, or acid, so that some of its original properties, especially its biological activity, are diminished or eliminated.
b. To cause the paired strands of (double-stranded DNA) to separate into individual single strands.
denature(dē-nā′chŭr) [ de- + nature]
1. In chemistry, to change the qualities of a substance, esp. to make alcohol (ethyl alcohol) unfit to drink by adding an unpleasant ingredient, e.g. methanol.
2. In biochemistry, to make a change in conditions (temperature, addition of a substance) that causes an irreversible change in the structure of a protein, usually resulting in precipitation of the protein.
2. In genetics, to separate double-stranded DNA into two complementary strands, usually with heat.denatured (′chŭrd), adjectivedenaturation (dē″nā″chŭ-rā′shŏn)
to deprive a substance of its natural qualities, e.g. by heating a protein to destroy its specific biological activity.