demyelinating disease


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demyelinating disease

 [de-mi´ĕ-lin-āt″ing]
any condition characterized by destruction of myelin.

de·my·e·li·nat·ing dis·ease

generic term for a group of diseases, of unknown cause, in which there is extensive loss of the myelin in the central nervous system, as in multiple sclerosis and Schilder disease.

de·my·e·li·nat·ing dis·ease

(dē-mī'ĕ-li-nāt-ing di-zēz')
Generic term for a group of diseases, of unknown cause, in which there is extensive loss of the myelin in the central nervous system, as in multiple sclerosis.

disease

traditionally defined as a finite abnormality of structure or function with an identifiable pathological or clinicopathological basis, and with a recognizable syndrome or constellation of clinical signs.
This definition has long since been widened to embrace subclinical diseases in which there is no tangible clinical syndrome but which are identifiable by chemical, hematological, biophysical, microbiological or immunological means. The definition is used even more widely to include failure to produce at expected levels in the presence of normal levels of nutritional supply and environmental quality. It is to be expected that the detection of residues of disqualifying chemicals in foods of animal origin will also come to be included within the scope of disease.
For specific diseases see under the specific name, e.g. Aujeszsky's disease, Bang's disease, foot-and-mouth disease.

air-borne disease
the causative agent is transmitted via the air without the need for intervention by other medium. See also wind-borne disease.
disease carrier
clinical disease
see clinical (3).
disease cluster
a group of animals with the same disease occurs at an unusual level of prevalence for the population as a whole. The cluster may be in space, with high concentrations in particular localities, or in time, with high concentrations in particular seasons or in particular years.
communicable disease
infectious disease in which the causative agents may pass or be carried from one animal to another directly or indirectly on inanimate objects or via vectors.
complicating disease
one that occurs in the course of some other disease as a complication.
constitutional disease
one involving a system of organs or one with widespread signs.
contagious disease
see communicable disease (above).
disease control
reducing the prevalence of a disease in a population, including eradication, by chemical, pharmaceutical, quarantine, management including culling, or other means or combinations of means.
disease control programs
organized routines specifying agents, administration, time and personnel allocations, community support, funding, participation of corporate or government agencies, animal and animal product disposal.
deficiency disease
a condition due to dietary or metabolic deficiency, including all diseases caused by an insufficient supply of essential nutrients.
degenerative joint disease
see degenerative joint disease, osteoarthritis.
demyelinating disease
any condition characterized by destruction of myelin.
disease determinant
any variable associated with a disease which, if removed or altered, results in a change in the incidence of the disease.
egg-borne disease
an infectious disease of birds in which the agent is spread via the egg.
endemic disease
see endemic.
environmental disease control
control by changing the environment, e.g. draining a swamp, ventilating a barn.
epidemic disease
etiological disease classification
diseases arranged in the order of their etiological agents, e.g. bacterial, mycoplasma.
exotic disease
a disease that does not occur in the subject country. Said of infectious diseases that may be introduced, e.g. rabies is exotic to the UK, contagious bovine pleuropneumonia is exotic to the USA.
focal disease
a localized disease.
fulminant disease
an explosive outbreak in a group or a rapidly developing, peracute development of a disease in an individual. Called also fulminating.
functional disease
any disease involving body functions but not associated with detectable organic lesion or change.
generalized disease
one involving all or many body systems; often said of infectious diseases in which there is spread via the bloodstream. See also systemic disease (below).
glycogen disease
any of a group of genetically determined disorders of glycogen metabolism, marked by abnormal storage of glycogen in the body tissues. See also glycogen storage disease.
heavy chain disease
hemolytic disease of newborn
see alloimmune hemolytic anemia of the newborn.
hemorrhagic disease of newborn
see neonatal hemorrhagic disease.
disease history
that part of a patient's history which relates only to the disease from which the patient is suffering.
holoendemic disease
most animals in the population are affected.
hyperendemic disease
the rate of infection is steady but high.
hypoendemic disease
the rate of infection is steady and only a few animals are infected.
immune complex disease
see immune complex disease.
infectious disease
one caused by small living organisms including viruses, bacteria, fungi, protozoa and metazoan parasites. It may be contagious in origin, result from nosocomial infections or be due to endogenous microflora of the nose and throat, skin or bowel. See also communicable disease (above).
manifestational disease classification
diseases arranged in the order of their clinical signs, epidemiological characteristics, necropsy lesions, e.g. sudden death diseases.
mesoendemic disease
the disease occurs at an even rate and a moderate proportion of animals are infected.
metabolic disease
see metabolic diseases.
molecular disease
any disease in which the pathogenesis can be traced to a single, precise chemical alteration, usually of a protein, which is either abnormal in structure or present in reduced amounts. The corresponding defect in the DNA coding for the protein may also be known.
multicausal disease
1. a number of causative agents are needed to combine to cause the disease.
2. the same disease can be caused by a number of different agents.
multifactorial disease
see multicausal disease (above).
new disease
disease not previously recorded. May be variants on an existing disease, e.g. infectious bovine rhinotracheitis, or escapes from other species, e.g. the Marburg virus disease of humans.
notifiable disease
a disease of which any occurrence is required by law to be notified to government authorities.
organic disease
see organic disease.
pandemic disease
a very widespread epidemic involving several countries or an entire continent.
quarantinable disease
a disease which the law requires to be restricted in its spread by putting the affected animals, farms or properties on which it occurs in quarantine.
reportable disease
see notifiable disease (above).
disease reservoir
any animal or fomite in which an infectious disease agent is preserved in a viable state or multiplies and upon which it may depend for survival.
secondary disease
1. a disease subsequent to or a consequence of another disease or condition.
2. a condition due to introduction of incompatible, immunologically competent cells into a host rendered incapable of rejecting them by heavy exposure to ionizing radiation.
self-limited disease
sex-limited disease
disease limited in its occurrence to one or other sex. See also sex-linked.
sexually transmitted disease (STD)
a disease that can be acquired by sexual intercourse.
slaughter disease control
see slaughter (2).
sporadic disease
occurring singly and haphazardly; widely scattered; not epidemic or endemic. See also sporadic bovine encephalomyelitis, sporadic leukosis, sporadic lymphangitis.
storage disease
disease syndrome
systemic disease
sufficiently widespread in the body to cause clinical signs referable to any organ or system, and in which localization of infection may occur in any organ.
disease triangle
interaction between the host, the disease agent, and the environment.
disease wastage
loss of income generated by production of milk, eggs, fiber, or loss of capital value because of diminution in the patient's value.
wasting disease
any disease marked especially by progressive emaciation and weakness.
zoonotic disease
disease capable of spread from animals to humans. See also zoonosis.
References in periodicals archive ?
Acute focal demyelinating disease simulating brain tumors: histopathologic guidelines for an accurate diagnosis.
We believe that MAID may be a unique form of acute, monofocal, cerebral demyelinating disease that clinically and neuroradiologically mimics a malignant brain tumor.
There are no formal guidelines to specify when treatment failure or resistance to therapy occurs; this distinction is based on the neurologist's experience with demyelinating disease and the overall impression of the patient's condition based on that knowledge.
Demyelinating disease as the assumed cause of hearing loss and vertigo.
Their research also is important because it supports a mechanism for visual loss in demyelinating disease outside of the traditional immune-activated inflammation research.
Acute disseminated encephalomyelitis (ADEM) is a rare idiopathic inflammatory demyelinating disease of the central nervous system (CNS), which usually occurs following viral/bacterial infections or vaccinations (1).
The results suggest that in patients with a clinically isolated syndrome, even a few characteristic MRI lesions are specific for demyelinating disease once appropriate alternative diagnoses have been excluded.
While a biopsy is rarely necessary for diagnosis in typical relapsing remitting MS, fulminant demyelinating disease may present as a solitary, rapidly expanding mass lesion with radiographic enhancement and features suggestive of a neoplasm and biopsy is often necessary for definitive diagnosis.
Two groups of colleagues from the University of Cflifornia, San Diego and the Mayo Clinic have confirmed it with mice afflicted with a chronic viral demyelinating disease.
Kodadek also announced the discovery of peptoids that capture autoantibodies diagnostic for the demyelinating disease Neuromyelitis Optica (NMO).