By contrast, Pattern 3 lesions had ill-defined borders, were not centred on vessels, lacked IgG and complement deposition and in 8/22 cases exhibited concentric bands of demyelinated and myelinated tissue at the lesion edge.
Parenchymal T-cells are almost absent in prephagocytic zones, are present in only modest numbers in regions of active phagocytosis and reach maximum densities in recently demyelinated, post-phagocytic tissue packed with lipid-laden macrophages (Henderson et al.
Effects of 4-aminopyridine on normal and demyelinated mammalian nerve fibers.
Effects of 4-aminopyridine on demyelinated axons, synapses and muscle tension.
Demyelinated fibers are sensitive to small changes in temperature and electrolytes, which can quickly produce conduction block.
Schauf and Davis further suggested that altering sodium and potassium channels might help to produce increased current density in demyelinated fibers, thereby minimizing the degree of conduction block.
Building on that model, Sejnowski and his team included myelin in their own model, then demyelinated
one of the sections and incorporated all the changes known to take place as a result.
And the axons were able to follow very high frequency stimulation, meaning impulses didn't stumble or stutter as their number increased, as they do in demyelinated nerves.
Would remyelination work on nerve fibers that have been demyelinated for many years?
n cats removed from the diet, recovery was slow, but all of the previously demyelinated
axons became remyelinated.
This was the first time that cultured Schwann cells had been used to repair experimentally demyelinated
areas of the CNS.
The drug restores nerve conduction by blocking exposed potassium channels in demyelinated
nerve processes, or axons.