delayed graft function


Also found in: Acronyms.

delayed graft function

A form of acute renal failure resulting in post-transplantation oliguria, increased allograft immunogenicity and risk of acute rejection episodes, and decreased long-term survival, which are linked to the donor and prerenal, renal or postrenal transplant factors related to the recipient.
 
Pathogenesis
Delayed graft function is linked to ischaemia and reinstitution of blood flow in ischaemically damaged kidneys after hypothermic preservation.
References in periodicals archive ?
Following successful completion of the phase 1 trial, the company plans to conduct a two-part multi-centered, double blinded and placebo controlled clinical study to evaluate the safety, tolerability and efficacy of OPN-305 in renal transplant patients at high risk of Delayed Graft Function (DGF) as the first clinical target indication for the development of OPN-305 to be initiated in 2012.
1] On the other hand, in the face of delayed graft function (DGF) having PD catheter in place postoperatively leaves the potential to use that catheter for temporizing peritoneal dialysis while waiting for the allograft to recover function.
Catalyst is focusing its product development efforts on drug candidates for hemophilia, non-hemophilic bleeding, and complement-driven diseases, including the prevention of delayed graft function and inflammation.
DELKENHEIM, Germany, January 20, 2011 /PRNewswire/ -- A diagnostic test for early detection of acute kidney injury may assist in predicting delayed graft function (DGF) in kidney transplant patients, according to a Finnish study published in Kidney International, the journal of the International Society of Nephrology.
Fremont, CA, announced that the FDA has granted orphan drug designation for QPI-1002, a synthetic siRNA targeting p53 mRNA for the prophylaxis of delayed graft function (DGF) in kidney transplant patients.
We plan to initiate clinical testing of FG-4539 in renal injuries beginning with delayed graft function.
Both these contemporary studies confirm older reports by Sumrani and colleagues who showed that patients undergoing AN prior to re-transplantation had a higher %PRA and thus a higher incidence of delayed graft function in subsequent transplants.
And importantly, we intend to initiate Phase 2 clinical testing of C1-INH in antibody mediated rejection and delayed graft function, as well as VP20621 for prevention of recurrence of C.
With its world-leading expertise in transplantation and acute care Novartis will provide invaluable support to the global development of QPI-1002, in development for the prevention of acute kidney injury (AKI) in patients undergoing cardiac surgery and for delayed graft function (DGF) in kidney transplant patients.
Based on these studies, we believe prevention of delayed graft function in renal transplantation and hemorrhagic shock associated with trauma, represent significant opportunities.
Based on Silence's AtuRNAi technology, Quark is developing its QPI-1002 for the prevention of acute kidney injury (AKI) in patients undergoing major cardiovascular surgery, and for the prophylaxis of delayed graft function (DGF) in patients receiving deceased donor kidney transplants.
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