DIO2

(redirected from deiodinase, iodothyronine, type II)

DIO2

A gene on chromosome 14q24.2-q24.3 that encodes a protein of the iodothyronine deiodinase family which activates thyroid hormone, converting prohormone thyroxine (T4) by outer-ring deiodination to bioactive 3,3’,5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas.
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