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Related to dehydroepiandrosterone: Dehydroepiandrosterone sulfate


an androgen occurring in normal human urine and synthesized from cholesterol; its level decreases with age.

de·hy·dro·ep·i·an·dros·ter·one (DHEA),

A steroid secreted chiefly by the adrenal cortex, but also by the testis; it is the principal precursor of urinary 17-ketosteroids. Weakly androgenic itself, it is metabolized to δ-5 androstenediol, a hormone with both androgenic and estrogenic effects, and is one of the precursors of testosterone. Serum levels are elevated in adrenal virilism. It may function as a neurotransmitter.

DHEA secretion begins during fetal life, reaches a peak in the third decade, and declines steadily thereafter; the level at age 80 is only 10-20% of the peak level. This decline has been speculatively associated with the changes of aging. Commercial formulations of DHEA are marketed as dietary supplements, although this substance is neither a nutrient nor a component of the human food chain. DHEA has been promoted for the prevention of degenerative diseases including atherosclerosis, Alzheimer dementia, parkinsonism, and other effects of aging. None of the alleged benefits has been demonstrated in large, randomized clinical trials. Limited studies in animals and human subjects suggest that DHEA reduces the percentage of body fat, perhaps by blocking the storage of energy as fat. Long-term administration to postmenopausal women has been associated with insulin resistance, hypertension, and reduction of LDL cholesterol levels. An analysis of 16 preparations of DHEA by high-performance liquid chromatography showed a variation in content from 0-150% of the labeled strength; only seven products fell between the expected 90-110% of labeled strength.


/de·hy·dro·epi·an·dros·ter·one/ (DHEA) (-ep″e-an-dros´ter-ōn) a steroid secreted by the adrenal cortex, the major androgen precursor in females; often present in excessive amounts in patients with adrenal virilism.




(DHEA) (dē-hī'drō-ep-ē-an-dros'tĕr-ōn)
Steroid agent related to male hormones that has been advocated as able to prevent physiologic consequences of aging, without studies that confirm benefit or safety.


Quantitatively the principal male sex hormone (ANDROGEN), of the adrenal cortex. Output declines with age, a decline thought by some to be causally related to ageing and to the development of various diseases. It is thought likely that, given to elderly people in dosage that would restore the blood levels to those of young adults, the hormone would improve physical and psychological well-being. The hormone has also been claimed to be effective in treating depression and osteoporosis.


n See DHEA.


an androgen occurring in normal human urine and synthesized from cholesterol.

Patient discussion about dehydroepiandrosterone

Q. Is DHEA supplement beneficial, if so to what extent? I am an athlete and a high school student. I gain extra fat during exam time and it becomes difficult to shed them easily. Is DHEA supplement beneficial, if so to what extent?

A. Hi. I would pay attention to the warnings in the answers from Corey and Aprilbean. I've checked it out in my book on Nutrituonal Healing and you are still at an age when your body is producing it naturally. It declines later in life, especially after 40. It said; "CAUTION SHOULD BE EXERCISED WHEN TAKING THIS SUPPLEMENT". Some physicians believe that it may suppress the bodies natural ability to synthesize this hormone. High doses can lead to liver damage. I'd rethink this idea Waylon.

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References in periodicals archive ?
Effects of chronic administration of dehydroepiandrosterone on serum testosterone levels and prostatic tissue in rats.
The first, PB005 (an injectable formulation of dehydroepiandrosterone sulphate or DHEAS), is in Phase II Clinical testing for acute asthma, severe burns and reconstructive surgery.
Effects of dehydroepiandrosterone replacement therapy on bone mineral density in older adults: a randomized, controlled trial.
Pharmadigm's second product, PB007, a proprietary injectable formulation of dehydroepiandrosterone (DHEA), is being evaluated as an inhibitor of tissue damage associated with vascular surgery, myocardial infarction and stroke.
Testosterone, androstenedione, dehydroepiandrosterone, and other anabolic steroids: oxandrolone, stanozolol, etc.
LISBON -- Dehydroepiandrosterone supplementation was no match for the powerful effects of ovarian aging in women with diminished ovarian reserve in the DITTO trial.
Six-month oral dehydroepiandrosterone supplementation in early and late postmenopause.
Although, there is a lack of clarity regarding etiopathogenesis, increased dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) levels may have an essential role in the appearance of PCOS symptoms.
The test segment is further classified into 11 major hormone tests that includes estradiol (E2), Follicle Stimulating Hormone (FSH), Human Chorionic Gonadotropin (hCG), Luteinizing hormone (LH), Dehydroepiandrosterone sulfate (DHEAS), progesterone, testosterone, Thyroid Stimulating Hormone (TSH), prolactin, cortisol and insulin tests.
Sex glow' is also caused by your body's release of dehydroepiandrosterone, (DHEA) - a male hormone, which promotes healthy skin and improves your complexion.
Researchers from a wide range of medical specialties look at estrogens, progestine, allopregnanoline, and neuroprotection; glucocorticoids, dehydroepiandrosterone, neuroprotection, and neuropathy; polypeptide hormones and neuroprotection;and hormones and neurogenesis.