degranulation


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de·gran·u·la·tion

(dē-gran'yū-lā'shŭn),
Disappearance or loss of cytoplasmic granules from a cell or activation of granulocytic cells (for example, neutrophils, mast cells, basophils, eosinophils).

degranulation

(dē-grăn′yə-lā′shən)
n.
The process of losing granules.

degranulation

[dēgran′yəlā′shən]
the release of granules from cells, such as mast cells and basophils.

degranulation

the loss of granules; usually refers to the secretory granules in certain cells, e.g. pituitary chromophobes, acidophils and basophils. In basophils and mast cells, it is associated with the release of active substances from the cells and is characteristic of type I immediate hypersensitivity.
References in periodicals archive ?
Induction of human cutaneous mast cell degranulation by opiates and endogenous opioid peptides: evidence for opiate and nonopiate receptor participation.
20,91) Mast cell infiltration, which might precede eosinophilic infiltration, liberates chemoattractant molecules that recruit eosinophils, which further induce esophageal tissue damage, in turn, increasing mast cell degranulation.
The enhancing effects of DEHP paralleled the infiltration of eosinophils, mast cell degranulation, and the expression of proinflammatory proteins in inflamed skin.
The beta-1,3-glucanbinding protein from the crayfish Pacifastacus leniusculus, when reacted with a beta-l,3-glucan, induces spreading and degranulation of crayfish granular cells.
IFN-[gamma] protects against chronic myocarditis by reducing mast cell degranulation, fibrosis, and the profibrotic cytokines TGF-[beta] 1, IL-1 [beta], and IL-4 in the heart.
IgE can cause mast cell degranulation, and IgG 1 can cause polymorphonuclear cells to become activated and degranulate.
Patients should be advised to avoid factors that precipitate mast cell degranulation.
Indeed, despite its overall conclusions, if taken seriously the paper's content appears to provide independent confirmation to the main claims made in Benveniste's original article , except that no recursive degranulation waves are recognizable.
The Synta CRACM channel inhibitors have shown strong anti-inflammatory activity in preclinical studies both in vitro and in vivo, inhibiting T cell and mast cell activity, including cytokine release, degranulation, and immune cell proliferation.
Mast cells of psoriatic and atopic dermatitis skin are positive for TNF-alpha and their degranulation is associated with expression of ICAM-1 in the epidermis.
lgE, by its function as a trigger of mast cell degranulation in allergy, has an acceptable though not excellent correlation with both the degree of the inflammatory response and the severity of clinical effects.
Although anaphylaxis is predominantly a clinical diagnosis, a serum tryptase level, taken 30 minutes after the reaction occurs (immediately on presentation to a facility if occurring in the ambulatory setting), 1 - 2 hours later and 12 - 24 hours later, may show a characteristic rise and then fall to baseline levels due to mast cell degranulation.