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degranulation |
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degranulation [dēgran′yəlā′shən] the release of granules from cells, such as mast cells and basophils. degranulation the loss of granules; usually refers to the secretory granules in certain cells, e.g. pituitary chromophobes, acidophils and basophils. In basophils and mast cells, it is associated with the release of active substances from the cells and is characteristic of type I immediate hypersensitivity. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Cells do not adhere to the device, and no degranulation or distortion is seen after staining. Although the local administration of carrageenan causes neutrophil migration, edema, and NSAID-sensitive hyperalgesia, the local administration of 1% formalin causes ordinary mast cell degranulation. Der p 1 induces production of proinflammatory cytokines in vitro [interletddn (IL)-8, IL-6, granulocyte-macrophage colony-stimulating factor] and induces IgE-independent mast cell and basophil degranulation (King et al. |
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