Induction of human cutaneous mast cell degranulation
by opiates and endogenous opioid peptides: evidence for opiate and nonopiate receptor participation.
20,91) Mast cell infiltration, which might precede eosinophilic infiltration, liberates chemoattractant molecules that recruit eosinophils, which further induce esophageal tissue damage, in turn, increasing mast cell degranulation
The enhancing effects of DEHP paralleled the infiltration of eosinophils, mast cell degranulation
, and the expression of proinflammatory proteins in inflamed skin.
The beta-1,3-glucanbinding protein from the crayfish Pacifastacus leniusculus, when reacted with a beta-l,3-glucan, induces spreading and degranulation
of crayfish granular cells.
IFN-[gamma] protects against chronic myocarditis by reducing mast cell degranulation
, fibrosis, and the profibrotic cytokines TGF-[beta] 1, IL-1 [beta], and IL-4 in the heart.
IgE can cause mast cell degranulation
, and IgG 1 can cause polymorphonuclear cells to become activated and degranulate.
Patients should be advised to avoid factors that precipitate mast cell degranulation
Indeed, despite its overall conclusions, if taken seriously the paper's content appears to provide independent confirmation to the main claims made in Benveniste's original article , except that no recursive degranulation
waves are recognizable.
The Synta CRACM channel inhibitors have shown strong anti-inflammatory activity in preclinical studies both in vitro and in vivo, inhibiting T cell and mast cell activity, including cytokine release, degranulation
, and immune cell proliferation.
Mast cells of psoriatic and atopic dermatitis skin are positive for TNF-alpha and their degranulation
is associated with expression of ICAM-1 in the epidermis.
lgE, by its function as a trigger of mast cell degranulation
in allergy, has an acceptable though not excellent correlation with both the degree of the inflammatory response and the severity of clinical effects.
Although anaphylaxis is predominantly a clinical diagnosis, a serum tryptase level, taken 30 minutes after the reaction occurs (immediately on presentation to a facility if occurring in the ambulatory setting), 1 - 2 hours later and 12 - 24 hours later, may show a characteristic rise and then fall to baseline levels due to mast cell degranulation