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degranulation |
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degranulation [dēgran′yəlā′shən] the release of granules from cells, such as mast cells and basophils. degranulation the loss of granules; usually refers to the secretory granules in certain cells, e.g. pituitary chromophobes, acidophils and basophils. In basophils and mast cells, it is associated with the release of active substances from the cells and is characteristic of type I immediate hypersensitivity. How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Selectin "shedding" occurs because infected cells degranulate, including an EDTA-inhibitable sheddase (metalloprotease), [beta]2-integrins, CD66b, and other inflammatory components such as matrix metalloproteases, which includes gelatinase (MMP9) (38,39). Magnesium probably stabilizes eosinophils (which under certain conditions degranulate major basic protein) and mast cells (which degranulate histamine). 2000 Diesel exhaust particles directly induce activated mast cells to degranulate and increase histamine levels and symptom severity J Allergy Clin Immunol 106:1140-1146. |
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