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degranulation
(redirected from degranulate)

   Also found in: Dictionary/thesaurus 0.01 sec.
degranulation
[dēgran′yəlā′shən]
the release of granules from cells, such as mast cells and basophils.

degranulation
the loss of granules; usually refers to the secretory granules in certain cells, e.g. pituitary chromophobes, acidophils and basophils. In basophils and mast cells, it is associated with the release of active substances from the cells and is characteristic of type I immediate hypersensitivity.


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Diesel exhaust particles directly induce activated mast cells to degranulate and increase histamine levels and symptom severity.
During that time, the mast cell membrane degranulates, and preformed mediators of inflammation are unleashed.
They contain granules rich in histamine that degranulate and released the histamine when the immune system detects foreign bodies such as pollen grains and dust mites, especially when the body has created antigens against them.
 
 
 
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