degranulation

(redirected from degranulate)
Also found in: Dictionary.

de·gran·u·la·tion

(dē-gran'yū-lā'shŭn),
Disappearance or loss of cytoplasmic granules from a cell or activation of granulocytic cells (for example, neutrophils, mast cells, basophils, eosinophils).

degranulation

(dē-grăn′yə-lā′shən)
n.
The process of losing granules.

degranulation

[dēgran′yəlā′shən]
the release of granules from cells, such as mast cells and basophils.

degranulation

the loss of granules; usually refers to the secretory granules in certain cells, e.g. pituitary chromophobes, acidophils and basophils. In basophils and mast cells, it is associated with the release of active substances from the cells and is characteristic of type I immediate hypersensitivity.
References in periodicals archive ?
IgE can cause mast cell degranulation, and IgG 1 can cause polymorphonuclear cells to become activated and degranulate.
The interaction term induces a transition probability between the unperturbed states of the basophils and the state where they will degranulate.
When the skin or mucous membranes are reexposed to the allergen(s), IgE bound to the receptors on the surface of the aforementioned cells causes them to degranulate and release histamine, pros-taglandin, leukotrienes, etc.
As a result of allergic sensitization, mast cells degranulate and release various biological mediators in allergen-specific IgE-mediated AD (Amin, 2012).
Diesel exhaust particles directly induce activated mast cells to degranulate and increase histamine levels and symptom severity.
When a person comes in frequent contact with a certain antigen or antigens to which the body has formed immunoglobulin (IgE) antibodies, antigen-antibody reactions occur along the surface of mast cells, causing the cells to degranulate.
It seems in this case, that although massively increased in number as shown on the bone marrow biopsy, her mast cells were remarkably stable and not triggered to degranulate by any of the usual factors.
During repair platelets become entrapped in a fibrin clot and degranulate releasing two primary growth factors: PDGF and TGF-B.
The neutrophils then degranulate and secrete prostaglandin metabolites that contribute to more endothelial damage, which leads to thrombosis, ischemia, and necrosis.
white blood cell) into tissues, where they can degranulate causing
Immunoglobulin E binding to mast cells "sensitizes" the mast cells to degranulate when multivalent antigens cross-link Fc[Epsilon]R-bound IgE (Figure).