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deformability |
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deformability /de·form·a·bil·i·ty/ (de-form?ah-bil´it-e) ability of cells to change shape when passing through narrow spaces, such as erythrocytes passing through the microvasculature. deformability the ability of cells, such as erythrocytes, to change shape as they pass through narrow spaces, such as the microvasculature. |
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| Morphological changes in erythrocytes may result in increased fragility, decreased viability, and decreased deformability of the cells as well as the release of a number of substances resulting in such adverse systemic responses as fever, cellular injury, alterations in regional and global blood flow, and organ dysfunction. Activation of monocytes and PMNs increases expression of CD11b and CD18 and decreases cell deformability through actin polymerization (Anderson et al. 005) and enhancement of mechanical properties including increased modulus and yield stress without the loss of deformability and elongation to break. |
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deformability
