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Improvement of erythropoiesis during treatment with deferiprone in a patient with myelofibrosis and transfusional hemosiderosis.
sup][136] The chelator deferiprone has an advantage over desferrioxamine, a 12-month study in patients with early-stage PD revealed a meaningful reduction in iron levels and improvement in motor symptoms,[sup][137] and several Phase II clinical trials evaluating deferiprone are ongoing [Table 1].
Pineda, "Combined Therapy with Idebenone and Deferiprone in Patients with Friedreich's Ataxia," Cerebellum, vol.
Cells were then washed twice and treated with deferiprone or deferoxamine (Ferriprox; Cat No.
Our previous preclinical, translational and pilot clinical studies demonstrated that novel iron chelation therapy with the prototypic drug deferiprone (DFP) (i) induces neuroprotection in cell models of PD via a powerful antioxidant effect, (ii) reduces regional siderosis of the brain, (iii) reduces motor handicap via inhibition of catechol-o-methyl transferase, and (iv) slows the progression of motor handicap in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model and in early PD patients.
Safety of oral iron chelator deferiprone in young thalassemias.
In a small pilot study, he and colleagues found that an iron-slurping chelator called deferiprone may have promise.
All patients had been diagnosed with either [beta]-thalassemia major (BTM) or [beta]-thalassemia intermedia (BTI), and all had received at least 1 year of treatment within the previous year with an iron chelator--either deferasirox, desferrioxamine (deferoxamine in the United States), deferiprone, or a combination of desferrioxamine and deferiprone.
Oral chelators deferasirox and deferiprone for transfusional iron overload in thalassemia major: new data, new questions.
Patients who were receiving frequent blood transfusions to maintain a pre-transfusion haemoglobin level of 9 g/dL and were on chelation therapy with Desferrioxamine or Deferiprone were selected for this study.
She also undergoes iron chelation therapy to remove the excess iron from her body by taking various medicines, including deferoxamine and deferiprone which cost P26,000 a month, Ana Liza said.