deep sequencing


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deep sequencing

Examination of a nucleic acid genome with such precision that even very rare genetic mutations are identified.
See also: sequencing
References in periodicals archive ?
No samples except the one initially detected by deep sequencing were PCR positive, yielding a low prevalence of 0.
Over the last decade, technology and inquisitive minds have created new directions in research and the next-generation of deep sequencing technologies.
These include a high-resolution flow cytometric method suited to analyze individual nano-sized vesicles, RNA deep sequencing with previously developed data analysis methods, and super-resolution microscopic imaging.
To characterize DRV, we performed random sequence amplification and deep sequencing with the 454 GS Junior Instrument (Roche, Basel, Switzerland) with DRV-infected Vero cell supernatants as described (6).
Deep sequencing of the HCV NS3/4A region confirms low prevalence of telaprevir-resistant variants both at baseline and end of study[sup.
Several samples with known mtDNA deletions were analyzed by LR-PCR followed by deep sequencing (Fig.
The team 'knocked it out of the park' by deep sequencing exceptionally rare familial cases and unrelated cases to identify the culprit pathway.
Leveraging RainDance's proven single-molecule picodroplet PCR technology, the ThunderStorm System supports a wide range of sequencing applications, including candidate gene screening, deep sequencing of heterogeneous tumor samples and medical genetics testing.
Sept 2, 2011), Identification and remediation of biases in the activity of RNA ligases in small-RNA deep sequencing Nuc Acid Res, 1--12.
Deep sequencing analyses of low density microbial communities: working at the boundary of accurate mi crobiota detection.
Adam Polermo, Genzyme, present the latest data on the implementation of deep sequencing technologies
The fellow aims to genetically characterize CTCs and CTD over time by high-throughput targeted deep sequencing to elucidate the processes underlying metastasis and evolution of resistance in prostate cancer.