dedifferentiation


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anaplasia

 [an″ah-pla´zhah]
loss of differentiation of cells and their orientation to each other, a characteristic of tumor cells; called also dedifferentiation and undifferentiation.

de·dif·fer·en·ti·a·tion

(dē-dif'ĕr-en'shē-ā'shŭn),
1. The return of parts to a more homogeneous state.
2. Synonym(s): anaplasia

dedifferentiation

/de·dif·fer·en·ti·a·tion/ (de-dif″er-en″she-a´shun) anaplasia.

dedifferentiation

(dē′dĭf-ə-rĕn′shē-ā′shən)
n. Biology
Reversion of a specialized cell or tissue to an unspecialized form. Dedifferentiation may occur before the regeneration of appendages in plants and certain animals and in the development of some cancers.

de′dif·fer·en′ti·ate′ v.

dedifferentiation

See anaplasia.

dedifferentiation

Pathology
The reversion of a cell or cell line to a more embryonic form.
 
Tumour biology
The loss of the cellular features of terminal differentiation, a finding often associated with increased aggressiveness of a neoplasm.

de·dif·fer·en·ti·a·tion

(dē-dif'ĕr-en'shē-ā'shŭn)
1. The return of parts to a more homogeneous state.
2. Synonym(s): anaplasia.

dedifferentiation

a process in which tissues that have undergone CELL DIFFERENTIATION can be made to reverse the process so as to become a primordial cell again (see GURDON). In theory, all cells should possess this ability since the mature cell does not lose DNA (see TOTIPOTENCY), but reversal has been demonstrated in plants much more easily than in animal cells.

dedifferentiation

regression from a more specialized or complex form to a simpler state.
References in periodicals archive ?
In van der Hoven's view, then, it is not narrow vocationalism that is driving the students; they are rather trying to empower themselves under the pressures of dedifferentiation and the decline of experience.
By interfering with normal follicular dendritic cell function, age likely has the same effect on transmissible spongiform encephalopathies as has been observed due to dedifferentiation of follicular dendritic cells (8).
SCREENING FOR CELL DEDIFFERENTIATION MUTANTS IN ARABIDOPSIS
His own large studies in animals raise further concerns: Biopsies at 1 year show evidence of cellular migration and dedifferentiation.
It would prevent dedifferentiation once development is completed, and hence acts as a cancer preventive in relatively high concentration after development.
This makes him symbolize the erupting bodily fluids that signify the dedifferentiation of death.
VanVeelen M, Avezaat C, Kros J et al: Supratentorial low grade astrocytoma: Prognostic factors, dedifferentiation, and the issue of early vs.
Then, various specialized cells at the site, such as bone, skin, and blood cells, lose their identity in a process called dedifferentiation.
Forces affecting the industry and market for anti-cancer medicines Our report discusses issues and events affecting that industry and market from 2014, including these: -- Epidemiology C incidence, prevalence, mortality and survival -- Resistance to treatment, tumour (tumour) heterogeneity, dedifferentiation, invasiveness and metastasis -- Personalised medicine, targeted therapy, in vivo diagnostics (IVD) and theranostics -- Cost-effectiveness, pricing and reimbursement -- Payers and healthcare policy.
6] Early upgrading following repeat biopsy is concerning for initial sampling error, whereas later upgrading may represent true dedifferentiation of prostate cancer.
The best entry into the show's framework of dedifferentiation and pollution of diverse systems, which the notion of "contamination" sought to encapsulate, was Rachel Rose's video Sitting Feeding Sleeping, 2013.
The usual Reckeweg table includes phase 1, excretion; phase 2, inflammation; phase 3, deposition; phase 4, impregnation; phase 5, degeneration; phase 6, dedifferentiation.