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dedifferentiation

   Also found in: Dictionary/thesaurus, Wikipedia 0.07 sec.
dedifferentiation /de·dif·fer·en·ti·a·tion/ (de-dif″er-en″she-a´shun) anaplasia.
de·dif·fer·en·ti·a·tion (ddf--rnsh-shn)
n.
Regression of a specialized cell or tissue to a simpler unspecialized form.
dedif·fer·enti·ate v.
dedifferentiation.
See anaplasia.
dedifferentiation
regression from a more specialized or complex form to a simpler state.


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The well-differentiated and myxoid types are associated with uniformly good outcomes, including lower recurrence rates (30 to 50%) and excellent survival (75 to 100% at 5 yr); also, these two types do not metastasize unless they undergo dedifferentiation to a high-grade liposarcoma, which is a rare, time-dependent process most often associated with incompletely treated and multiply recurrent liposarcomas.
Liposarcoma of the tongue: case report and review of the literature by Shen, Yuenan / Ear, Nose and Throat Journal
This dedifferentiation connects with a larger anxiety playing out across the show, also evident in a piece from another series, the epic, fifteen-part Soup Painting 2: Primordial Soup with Homoeopathic Dilutions, 2003-2004.
Keith Tyson: Haunch of Venison by Withers, Rachel / Artforum International
By interfering with normal follicular dendritic cell function, age likely has the same effect on transmissible spongiform encephalopathies as has been observed due to dedifferentiation of follicular dendritic cells (8).
Age and transmissible spongiform encephalopathies by Joly, Damien O. / Emerging Infectious Diseases
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