dedifferentiated


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Related to dedifferentiated: dedifferentiated liposarcoma

dedifferentiated

Referring to a cell or tissue which has acquired a less mature appearance and metabolic profile, an event classically associated with aggressive malignancies.
References in periodicals archive ?
Association of low-grade endometrioid carcinoma of the uterus and ovary with undifferentiated carcinoma: a new type of dedifferentiated carcinoma?
A diagnosis of retroperitoneal liposarcoma possibly dedifferentiated type extending along left inguinal canal was made on the basis of CT findings.
Dedifferentiated liposarcomas, more common to the retroperitoneum because of their association with large tumors, are bimorphic in appearance.
The complete cylinder of peripheral wood and bast is formed by a progressive lateral differentiation of the dedifferentiated parenchyma in the interfascicular areas.
In an attempt to resolve the impasse, the President's Council on Bioethics has identified four possible alternative sources of stem cells: stem cells obtained from already-deceased embryos; from living embryos by nondestructive biopsy; from dedifferentiated somatic cells; and from bioengineered embryo-like artifacts (entities engineered to develop like early embryos but lacking the biological capacity to implant and develop into human beings).
They have been reported in the bone and in dedifferentiated renal cell carcinoma.
Their libidinal significance is dedifferentiated, with the orifices all clustering as small egg-like shapes inside a round enclosure that is attached to one side of the concentric circles ten times its size.
The dedifferentiated cells are capable of reassigning their functions and destinations.
This dedifferentiated cell line exhibits an altered morphology with pseudopod extensions.
If the cervical ultrasound is negative, the patient has had one or two negative radioiodine whole-body scans, and the serum thyroglobulin remains high, then it's time to consider an FDG-PET scan to search for residual dedifferentiated disease that doesn't take up radioiodine, he suggested.
In fact, typical cancer cells appear to be in a less-than-mature, or dedifferentiated, state.
In December 2008, FUSILEV was listed in the National Comprehensive Cancer Network([R]) (NCCN) Drugs and Biologic Compendium[TM] to be used in combination with high-dose methotrexate for the treatment of bone cancer (osteosarcoma and dedifferentiated chrondrosarcoma), and the NCCN Clinical Practice Guidelines in Oncology[TM] in Colon Cancer and Rectal Cancer were updated to reflect that FUSILEV is available in the United States.