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dedifferentiation
(redirected from dedifferentiate)

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dedifferentiation /de·dif·fer·en·ti·a·tion/ (de-dif″er-en″she-a´shun) anaplasia.
de·dif·fer·en·ti·a·tion (ddf--rnsh-shn)
n.
Regression of a specialized cell or tissue to a simpler unspecialized form.
dedif·fer·enti·ate v.
dedifferentiation.
See anaplasia.
anaplasia [an″ah-pla´zhah]
loss of differentiation of cells and their orientation to each other, a characteristic of tumor cells; called also dedifferentiation and undifferentiation.
dedifferentiation
regression from a more specialized or complex form to a simpler state.
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It is possible, however, for these tumors to dedifferentiate further into a more aggressive form, with the possibility of metastasis.
Well-differentiated liposarcoma of the groin by Ly, Justin Q.; Lusk, Joanna D. / Applied Radiology
Then, selective inhibition of the excessive proliferation of VSMC is considered to have the potential to protect from vascular disorders as well as dedifferentiate VSMC from the synthetic to the contractile state and induce apoptosis.
Selective inhibition of vascular smooth muscle cell proliferation by ... by Tanabe, H.; Suzuki, H.; Nagatsu, A.; Mizukami, H.; Ogihara, Y.; Inoue, M. / Phytomedicine: International Journal of Phytotherapy & Phytopharmacology
As in nonmalignant tumors, cells have lost their normal control, often dedifferentiate, and grow in an inappropriate place.
Dioxins and endometriosis: a plausible hypothesis. (Research Review) by Cummings, Audrey M. / Environmental Health Perspectives
 
 
 
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