would allow the wound to be closed with normal tissue rather than scar tissue, bringing an end to disabling disfigurements caused by burns.
When the tissues are damaged, it is a race between scarring that quickly closes the wound with a 'patch' and regenerative healing that reconstructs more normal tissue - therefore our strategy is to use Decorin
to slow down the scarring process," added Prof Logan, who specialises in molecular neuroscience.
2,27) We detected a significant reduction in decorin
and lumican after 2 weeks of pBOO, consistent with a pro-fibrotic environment and deregulated collagen assembly.
In several different publications it has been described the ability of decorin
to affect a number of biological processes including inflammatory responses, wound healing, and angiogenesis.
If our suspicions are verified then this could mean that, in the future, measurement of decorin
levels could become a reliable diagnostic test for prostate cancer and also help determine how aggressive the disease is.
Candidate polysaccharide or proteoglycan subunits include aggrecan, agrin, bamacan, heparan sulfate, chondroitin sulfate, keratan sulfate, versican, phosphocan, perlecan, hyaluronan, decorin
, dermatan sulfate, biglycan, fibromodulin, alginate, polylactate, polyglycolic acid, starch, dextran, agarose, chitan, chitosan, and heparin.
To inhibit fibrosis formation following severe injury, attributed in large part to the secretion of transforming growth factor (TGF)- [beta] 1 , researchers have investigated the administration of TGF-[beta]1 specific inhibitors, such as relaxin , decorin
, and suramin [13-15].
The mRNA of decorin
was also stimulated, but elastin, and fibrillin 1 and 2 were not modified by the vitamin.
Syntaxin, IGFBP3, decorin
, the bax inhibitor gene and the PEBP gene were assigned to BTA 3, 4, 5, 5, and 17, respectively.
Two sequence-specific peptide antisera (LF-15 and LF-30) generated against synthetic peptides corresponding to amino acids 11-24 and 5-17 of the human core proteins of 2 small leucine-rich proteoglycans, biglycan and decorin
, were used to characterize territorial or interterritorial cartilage matrices.
Integra's research in San Diego will concentrate on developing its cartilage regeneration product, decorin
, RGD peptides and polymer research in combination with its proprietary collagen matrices.
paid US$500,000 to obtain certain rights to Telios' anti-TGF-Beta antibodies for fibrotic diseases and obtained right of first refusal for Telios' rights to decorin
, a mediator of TGF-Beta which plays an important role in dermal scarring and fibrotic diseases.