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decitabine |
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decitabine /de·ci·ta·bine/ (DAC) (de-si´tah-bēn″) a cytotoxic compound used as an antineoplastic in the treatment of acute leukemia. decitabine, an agent that prevents DNA methylation, halting growth of rapid proliferation blasts. indications This drug is used to treat naive and experienced myelodysplastic syndrome. contraindications Pregnancy, lactation, severe neurotoxicity, severe blood dyscrasias, and known hypersensitivity to this drug prohibit its use. Its use is also contraindicated in children. adverse effects Adverse effects of this drug include confusion, abdominal pain, dyspepsia, hematoma, and cellulitis. Life-threatening side effects include neutropenia, thrombocytopenia, leukopenia, and anemia. Common side effects include headache; anxiety; dizziness; hypoesthesia; insomnia; edema; murmur; hypotension; nausea; anorexia; vomiting; diarrhea; constipation; stomatitis; alopecia; ecchymosis; erythema; pallor; petechiae; pruritus; rash; swelling of the face; urticaria; decreased potassium, sodium, magnesium, and albumin; increased or decreased glucose; myalgia; arthralgia; back pain; chest wall pain; pain in the limbs; cough; crackles; hypoxia; pharyngitis; pneumonia; and pulmonary edema. decitabine Oncology An antimetabolic anticancer agent How to thank TFD for its existence? Tell a friend about us, add a link to this page, add the site to iGoogle, or visit webmaster's page for free fun content. |
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Issa notes that decitabine and other drugs that target gene methylation might work even better when administered with some traditional chemotherapy medications. Decitabine is currently in the latter stages of Phase III clinical testing in the United States for MDS. Phase II trial of decitabine in myelofibrosis with myeloid metaplasia" |
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