enzyme /en·zyme/ (en´zīm) a protein that catalyzes chemical reactions of other substances without itself being destroyed or altered upon completion of the reactions. Enzymes are divided into six main groups: oxidoreductases, transferases, hydrolases, lyases, isomerases, and ligases. Symbol E.
Enzyme
enzyme
enzyme (enˑ·zīm),
enzyme (en´zīm),
enzyme
Patient discussion about debrancher enzyme, debranching enzyme.
allosteric enzyme one whose catalytic activity is altered by binding of specific ligands at sites other than the substrate binding site.
brancher enzyme , branching enzyme 1,4-α-glucan branching enzyme: an enzyme that catalyzes the creation of branch points in glycogen (in plants, amylopectin); deficiency causes glycogen storage disease type IV.
constitutive enzyme one produced constantly, irrespective of environmental conditions or demand.
debrancher enzyme , debranching enzyme
2. any enzyme removing branches from macromolecules, usually polysaccharides, by cleaving at branch points.
induced enzyme , inducible enzyme one whose production can be stimulated by another compound, often a substrate or a structurally related molecule.
proteolytic enzyme peptidase.
repressible enzyme one whose rate of production is decreased as the concentration of certain metabolites is increased.
respiratory enzyme one that is part of an electron transport (respiratory) chain.
en·zyme ( n z m)n. Any of numerous proteins or conjugated proteins produced by living organisms and functioning as specialized catalysts for biochemical reactions. en  zy·matic (-z -m t k), en·zymic (-zmk, -zmk) adj. |   Top: substrate molecules bonding with an enzyme's active site Center: the substrate molecules and enzyme bind to form a single molecule Bottom: the new molecule and unchanged enzyme separate |
Enzyme
A substance produced by the body to assist in a chemical reaction. In carbohydrate intolerance, lack of an enzyme makes it impossible for one type of sugar to be broken down into a simpler form so that it can be absorbed by the intestines and used by the body.
Mentioned in: Abscess, Acid Phosphatase Test, Albinism, Aldolase Test, Alkaline Phosphatase Test, Amino Acid Disorders Screening, Amylase Tests, Angiotensin-Converting Enzyme Inhibitors, Antidiarrheal Drugs, Antiulcer Drugs, Beriberi, Carbohydrate Intolerance, Cholesterol-Reducing Drugs, Coagulation Disorders, Galactosemia, Gene Therapy, Genetic Testing, Glucose-6-Phosphate Dehydrogenase Deficiency, Insecticide Poisoning, Lactate Dehydrogenase Isoenzymes Test, Lactate Dehydrogenase Test, Lesch-Nyhan Syndrome, Mucopolysaccharidoses, Pancreatitis, Penicillins, Pharmacogenetics, Phenylketonuria, Porphyrias, Pyruvate Kinase Deficiency, X-Linked Agammaglobulinemia
enzyme
[en′zīm]
Etymology: Gk, en, in, zyme, ferment
a complex produced by living cells that catalyzes chemical reactions in organic matter. Most enzymes are produced in tiny quantities and catalyze reactions that take place within the cells. Digestive enzymes, however, are produced in relatively large quantities and act outside the cells in the lumen of the digestive tract. The substance that is acted upon by an enzyme is called a substrate.
enzyme (enˑ·zīm),
n protein that acts as a catalyst during chemical reactions.
enzyme (en´zīm),
n a protein substance that acts as a catalyst to speed up metabolic and other processes involving organic materials. Some enzymes function within cells; others function in the extracellular fluids and tissue spaces and organs. They are active in all major tissue functions, such as cellular respiration, muscle contraction, digestive processes, and energy consumption, and are produced intracellularly.
enzyme-linked immunosorbent assay (ELISA),
n a species-specific serologic laboratory procedure used to identify microorganisms infecting or inhabiting a tissue or organ system. Its dental use is in the identification of pathogens involved in periodontal disease.
enzyme
any protein that acts as a catalyst, increasing the rate at which a chemical reaction occurs. The animal body probably contains about 10,000 different enzymes. At body temperature, very few biochemical reactions proceed at a significant rate without the presence of an enzyme. Like all catalysts, an enzyme does not control the direction of the reaction; it increases the rates of the forward and reverse reactions proportionally.
activating enzyme
one that activates a given amino acid by attaching it to the corresponding transfer ribonucleic acid.
enzyme assays
several enzymes are important in clinical pathology. Enzymes characteristic of a tissue are released into the blood when the tissue is damaged, and enzyme levels in the blood can aid in the diagnosis or monitoring of specific diseases. Lipase and amylase levels are useful in pancreatic diseases; alkaline phosphatase (ALP), aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in liver diseases; and lactate dehydrogenase (LD), AST and creatine kinase (CK) in muscle disease. ALP is also released in bone diseases. Many enzymes have different forms (isoenzymes) in different organs. The isoenzymes can be separated by electrophoresis in order to determine the origin of the enzyme. Isoenzymes of LD, CK and ALP have the most clinical utility.
brancher enzyme, branching enzyme
amylo-(1,4→1,6)-transglycosylase; important in the synthesis of the branched glycogen molecule. Absence of the enzyme causes an increase in the length of the glucose chains and a decrease in the number of branch points in the glycogen molecules.
congenital enzyme deficiency
in humans hundreds of genetic diseases that result from deficiency of a single enzyme are now known. Many of these diseases fall into two large classes. The aminoacidopathies, e.g. phenylketonuria (PKU), result from deficiency of an enzyme in the major pathway for the metabolism of a specific amino acid. The amino acid accumulates in the blood, and it or its metabolites are excreted in the urine. The lysomal storage diseases, e.g. gangliosidosis, mannosidosis, result from deficiency of a lysomal enzyme and the accumulation of the substance degraded by that enzyme in lysosomes of cells throughout the body. The stored material is usually a complex substance, such as glycogen, a sphingolipid or a mucopolysaccharide. Many similar diseases are now identified in animals and are to be found under the specific name of each disease.
constitutive enzyme
one produced by a microorganism regardless of the presence or absence of the specific substrate acted upon.
core enzyme
the smallest aggregate of an enzyme's subunits that has enzymatic activity.
debrancher enzyme, debranching enzyme
dextrin-1,6-glucosidase: an enzyme that acts to move glucose residues of the glycogen molecule, and is important in glycogenolysis.
induced enzyme, inducible enzyme
one whose production requires or is stimulated by a specific small molecule, the inducer, which is the substrate of the enzyme or a compound structurally related to it.
enzyme induction
the effect some compounds such as phenobarbitone and phenytoin have in increasing the activity of microsomal hepatic enzymes. This may cause alterations in the metabolism of concurrently administered drugs.
microsomal e's
those associated with the endoplasmic reticulum of cells, particularly of the liver.
proteolytic enzyme
one that catalyzes the hydrolysis of proteins and various split products of proteins, the final product being small peptides and amino acids.
repressible enzyme
one whose rate of production is decreased as the concentration of certain metabolites is increased.
respiratory e's
enzymes of the mitochondria, e.g. cytochrome oxidase, which serve as catalysts for cellular oxidations.
restriction e's
enzyme
A protein substance which catalyses (i.e. enhances a chemical reaction in other bodies without undergoing a change in itself) and is formed by living cells but can act independently of their presence. Example: Enzyme preparations (containing pancreatin, papain or subtilisin A) used to break down tear proteins that become attached to the surface of contact lenses. See contact lens deposits; phagocytosis; surfactant; wetting solution.
enzyme
A protein that catalyzes most chemical reactions in biological systems without itself being destroyed or altered by the reaction; enzymes accelerate the rate of reactions by lowering transition state energy Enzyme Commission groups
Oxidoreductase, transferase, hydrolase, lyase, isomerase, ligase.
Patient discussion about debrancher enzyme, debranching enzyme.
Q. My muscle enzymes are at 355, my DR says normal is 200. She refered me to a Neurologist. What could be wrong? I am experiencing sore legs when I walk, weakness, and sometimes difficulty in swallowing. I am 46 I had a minor heart attack 5 yrs ago with a stent placed in my LAD. I am on Crestor 10mg. my Dr. has adjusted the dosage several times and used other drugs but it doesn't change the results much if at all.
A. Crestor itself may cause elevated muscle enzymes (you probably refer to Creatine Kinase, http://en.wikipedia.org/wiki/Creatine_kinase). However, weakness and swallowing problems may raise the suspicion of a disease of the nerves or muscles.
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