Aurigene's Programmed Death pathway
program is the first of several immune checkpoint programs that are at different stages of discovery and preclinical development.
Autophagy in response to cellular stress states serves as a potent death signal, as in the case of chemotherapy-induced autophagy, a specific non-apoptotic death pathway
has been triggered off.
By preventing cell-to-cell transmission, we may able to block the death pathway
and stop the progression from HIV infection to AIDS.
Preclinical studies suggest that TREANDA may lead to cell death by a process known as apoptosis (programmed cell death) as well as by an alternate cell death pathway
which disrupts normal cell division known as mitotic catastrophe (a non-apoptotic pathway).
Therefore, JNK is required for stress-induced activation of the cytochrome c-mediated death pathway
(Tournier et al.
Prof Patrick Pullicino, a consultant neurologist, told the Daily Mail: "The lack of evidence for initiating the Liverpool Care Pathway makes it an assisted death pathway
rather than a care pathway.
The researchers identified a novel receptor-mediated death pathway
in breast cancer cells specifically targeted by MDA-7.
This dephosphorylation relieves repression, allowing genes in a death pathway
to be transcribed, leading to lysis of the bacteria.
We are all looking for a unifying theme that might funnel all these different models into a common death pathway
," says Hockenbery, He and his co-workers speculate that - no matter what the specific death signal or cell type - once a cell is bent on dying, it does so via free radicals, turning loose a chain of ruinous chemical reactions that bcl-2 can counter.
In response to the stress, beta cells activate a cell death pathway
leading to the loss of beta cell mass in the animal.
The surprising aspect is that caspase 8 appears to have two functions: one that initiates apoptosis and a second that restrains an independent programmed death pathway
," says senior author Ed Mocarski.
Tumor profiling also showed a lack of PD-L1 (tumor infiltrating lymphocytes), which suggested to investigators that immune therapies targeting the programmed death pathway
may not be useful in SCCC.