The proteins, known as APOBEC cytidine deaminases
, cause clusters of mutations that can outnumber all others associated with cancer, say the researchers.
corresponding author of the paper, said that scientists knew the main functions of APOBEC cytosine deaminases
were to inactivate viruses that attack the body and prevent ancient viruses present in the human genome from moving around and causing disrupting mutations.
Non-Giusti methods includes the reduced nicotinamide adenine dinucleotide-linked kinetic method, ADA deaminases adenosine to inosine.
The analysis of pleural fluid adenosine deaminase (ADA) levels in the diagnosis of tuberculous pleural effusion (TPE) was established in 1978 by Piras et al (1).
Adenosine deaminase (ADA) is an enzyme in the purine salvage pathway that catalyses the conversion of adenosine and deoxyadenosine to inosine and deoxyinosine with the release of ammonia.
There are no international standardisation programs for adenosine deaminase assays and published cut-off should therefore be viewed with caution.
However, if clinical details suggest a high pre-test probability, adenosine deaminase results should be interpreted with caution.
Adenosine deaminase activity in pleural effusions: an aid to differential diagnosis.
Diagnostic value of adenosine deaminase in tuberculous pleural effusions: a meta-analysis.
A reduced nicotinamide adenine dinucleotide-linked kinetic assay for adenosine deaminase activity.