At the spinal level, amputation induces a state of deafferentation
silence, or at the very least disorganization, with abnormal discharges from neuromas and the dorsal root ganglia that have been disrupted .
Neurosurgeons, pain specialists, and other physicians from the US and Asia consider morphological brain changes; how thalamic burst-firing in response to experimental pain stimuli and in patients with chronic neuropathic pain may be a carrier for pain-related signals; brain activity in patients with chronic neuropathic pain resulting from input deafferentation
, brachial plexus avulsion, lateral thalamic vascular accident, and pain related to peripheral sources; surgical interventions; and thalamocortical abnormalities in spinal cord injury pain.
On the other hand, it has been shown that cholinergic deafferentation
of the hippocampus results in a delay in the decline of corticosterone levels, without interfering with the peak corticosterone response after stress (40).
A social deafferentation
hypothesis for induction of active schizophrenia.
Effect of chronic L-dopa or melatonin treatments after dopamine deafferentation
in rats: dyskinesia, motor performance, and cytological analysis.
Patients with spinal cord injury may often have symptoms of deafferentation
similar to amputees.
Anaesthetising the hand (peripheral deafferentation
) modifies brain activity and rapidly changes the way we perceive the outside world and our own body, concludes the researchers.
research with monkeys: implications for rehabilitation medicine.
contended that the color hallucinations were a result of selective deafferentation
, the elimination or interruption of sensory nerve fibers in the macula, and localized hyperexcitability of the color area in the ventral pathway of the brain.
Compared effects of hindlimb unloading versus terrestrial deafferentation
on muscular proprieties of the rat soleus.
I was a little surprised at just how frequently sedation occurred," he added, noting that the underlying mechanism for the sedation could be deafferentation
of the reticular activating system.
1995, Restoration of olfactory mediated behavior after olfactory bulb deafferentation