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deacylase

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deacylase /de·acyl·ase/ (de-as´il-ās) any hydrolase that catalyzes the cleavage of an acyl group in ester or amide linkage.
de·ac·yl·ase (d-s-ls, -lz)
n.
Any of a group of enzymes that catalyze the hydrolysis of an acyl group.


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The most prominent human member of this NAD+dependent protein deacylases is Sirt1.
Filaggrin deficiency appears to lead to impaired barrier function and a reduction in the activity of one of the key enzymes involved in bilayer formation, sphingomyelin deacylase, leading to reduced ceramide levels and altered lipid packaging.
He produced evidence suggesting that the high levels of expression of SM deacylase in atopic dermatitis explains the mechanism of ceramide deficiency leading to barrier disruption which is strongly linked to atopic skin's vulnerability to irritants or allergens.
 
 
 
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