DES diethylstilbestrol.
DES
DES,
diethylstilbestrol (DES) [di-eth″il-stil-bes´trol]
DES
DES (d  - s )n. Diethylstilbestrol; a synthetic nonsteroidal substance having estrogenic properties and once used to treat menstrual disorders. It is no longer used due to the incidence of certain vaginal cancers in the daughters of women so treated. |
DES
The abbreviation for diethylstilbestrol, a synthetic form of estrogen that was widely prescribed to women from 1940 to 1970 to prevent complications. It was linked to several serious birth defects and disorders of the reproductive system in daughters of women who took DES. In 1971, the FDA suggested it not be used during pregnancy and banned its use in 1979 as a growth promoter in livestock.
Mentioned in: Colposcopy
DES,
abbreviation for diethylstilbestrol.
diethylstilbestrol (DES) [di-eth″il-stil-bes´trol]
a synthetic nonsteroidal estrogen used for palliative treatment of prostatic carcinoma and sometimes advanced breast carcinoma. It was formerly used to relieve vasomotor symptoms associated with menopause, and in primary ovarian failure, female hypogonadism, atrophic vaginitis, kraurosis vulvae, and female castration. Most significantly, however, it was formerly widely used to prevent threatened abortion and premature labor. The female children who were thus exposed to the drug as fetuses have tended to have a variety of cervical abnormalities and an increased risk of clear cell adenocarcinoma of the reproductive tract. Male offspring have sometimes had abnormal genitalia, epididymal cysts, and abnormal semen analyses. Regular examinations and follow-up are indicated for these individuals.
DES
diethylstilbestrol.
DES
Diethylstilbestrol Gynecology A synthetic estrogen more potent than natural estrogens; DES use during pregnancy was banned in 1972, as in utero exposure before the 18th gestational wk results in a 3-fold ↑ in congental
abnormalities–without impairing fertility or sexual function—and vaginal wall adenosis in 35-70% of exposed ♀ infants; 0.14% of cases progress to vaginal adenocarcinoma; other DES changes include obliteration of vaginal fornices,
microglandular hyperplasia of the cervix–cervical ectropion, transverse ridging–appearance, and a 2.5-fold ↑ in 1º infertility Treatment Aggressive surgery–eg, vaginectomy, hysterectomy and lymphadenectomy. See Cockscomb
cervix.
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