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daptomycin

   Also found in: Wikipedia 0.01 sec.
daptomycin,
a miscellaneous antiinfective.
indications This drug is used to treat complicated skin and skin structure infections caused by Staphylococcus aureus (including methicillin-resistant strains), S. agalactiae, S. dysgalactiae, and Enterococcus faecalis (vancomycin-susceptible strains only).
contraindication Known hypersensitivity to this drug prohibits its use.
adverse effects Adverse effects of this drug include hypotension, hypertension, increased creatinine phosphokinase, nausea, constipation, diarrhea, vomiting, dyspepsia, headache, insomnia, dizziness, muscle pain or weakness, arthralgia, fungal infection, urinary tract infection, anemia, nephrotoxicity, rash, and pruritus. A life-threatening side effect is pseudomembranous colitis.


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Notably, the daptomycin MIC of the April isolate was reproducibly 2 [micro]g/mL, an increase from 1 [micro]g/mL for the February isolate.
Food and Drug Administration (FDA) approval to market a generic version of daptomycin prior to the expiration of Cubist's patent rights.
TPM's notice letter advised that it is seeking FDA approval to market daptomycin for injection prior to the expiration of US Patent Nos.
 
 
 
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