dapsone


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dapsone

 [dap´sōn]
an antibacterial used in treatment of leprosy and dermatitis herpetiformis and for prophylaxis of malaria caused by Plasmodium falciparum. Called also DDS.

dap·sone

(dap'sōn),
An antibiotic used to treat leprosy and certain cutaneous diseases such as dermatitis herpetiformis, is active against the tubercle bacillus, is used in the treatment of bovine coccidiosis and streptococcal mastitis, and is used as a second-line agent in Pneumocystis jiroveci [carinii] pneumonia.

dapsone

/dap·sone/ (dap´sōn) an antibacterial bacteriostatic for a broad spectrum of gram-positive and gram-negative organisms; used as a leprostatic, as a dermatitis herpetiformis suppressant, and in the prophylaxis of falciparum malaria.

dapsone

(dăp′sōn′, -zōn′)
n.
A sulfone drug, C12H12N2O2S, that is used primarily to treat leprosy and some forms of dermatitis.

dapsone (DDS)

[dap′sōn]
a bacteriostatic and bactericidal sulfone derivative.
indications It is prescribed in the treatment of leprosy and dermatitis herpetiformis and for prophylaxis against toxoplasmosis and Pneumocystis carinii in immunocompromised patients.
contraindications Known hypersensitivity to this drug prohibits its use. It is not recommended for use during pregnancy or lactation.
adverse effects Among the more serious adverse reactions are hemolysis (particularly in people who have glucose-6-phosphate dehydrogenase deficiency), leprosy reactional state, methemoglobinemia, neuropathy, nausea, anorexia, toxic hepatic aplastic anemia, and skin rash. Dapsone was carcinogenic in animal models.

dap·sone

(dap'sōn)
An antibiotic used to treat leprosy and cutaneous diseases such as dermatitis herpetiformis; active against the tubercle bacillus; used in the treatment of bovine coccidiosis and streptococcal mastitis and as a second-line agent in Pneumocystis jiroveci [carinii] pneumonia.

dapsone

Diaminodiphenyl sulfone. For many years this has been the standard drug to treat leprosy, but irregular use has led to the development of drug resistance. Dapsone is also used in the treatment of DERMATITIS HERPETIFORMIS which may be associated with COELIAC DISEASE.

dap·sone

(dap'sōn)
Antibiotic used to treat leprosy; active against the tubercle bacillus; used as a second-line agent in Pneumocystis jiroveci (carinii) pneumonia.

dapsone (DDS)

(dap´sōn),
n brand name: Avlosulfon;
drug class: leprostatic, antibacterial;
action: bactericidal and bacteriostatic against
M. leprae; may also be immunosuppressant;
uses: leprosy and dermatitis herpetiformis.

dapsone

an antibacterial used in humans for the treatment of leprosy and malaria. Used in cats to treat mycobacterial infections, particularly feline leprosy, caused by Mycobacterium lepraemurium.
References in periodicals archive ?
We present the case of a 62-year-old woman with chronic methemoglobinemia related to dapsone therapy for dermatitis herpetiformis who required shoulder arthroscopy for persistent shoulder pain and decreased range of motion.
Of the 10 patients who showed clinical or total remission, 10 (100%) had been treated with prednisone, 7 (70%) with cyclophosphamide, 3 (30%) with azathioprine, 3 (30%) with dapsone, 2 (20%) with minocycline, and 1 (10%) had plasmapheresis.
The development of sulfonamide resistance could result in the failure of sulfamethoxazole as well as dapsone, a sulfone antimicrobial agent also used in the treatment and prophylaxis of PCP.
3]) (8) Tacalcitol (9) Systemic Cyclosporine (10) Dapsone (11) Etanercept (12) Methotrexate (13) Psoralen + ultraviolet A (PUVA) (14) Retinoids (15) Surgical modalities (excision, dermabrasion, ablation, carbon dioxide laser) (16-22) Thalidomide (23) Other Intracutaneous botulinum toxin A (24) Photodynamic therapy with 5-aminolevulinic acid (25) Superficial radiotherapy (Grenz rays) (26) Electron beam radiotherapy (27)
Because both episodes of each patient were caused by the same P carinii types and because all patients received co-trimoxazole or dapsone as treatment, maintenance therapy, or both, these results strongly suggest that selection of P.
with dapsone use, particularly in the elderly population.
Representing the first new molecule in a decade approved by the FDA for the topical treatment of acne in patients 12 years of age and older, ACZONE(R) Gel 5% combines dapsone in a Solvent Microparticulate(TM)gel, enabling dapsone to be applied topically in a well-tolerated formulation to provide patients with a convenient and effective therapy.
Kalisiak and his colleagues began daily treatment with 600 mg of rifampin, 100 mg of dapsone, 50 mg of clofazimine.
Sulfa drugs such as dapsone, sulfapyridine, and sulfasalazine have also shown some utility (11).
OTCBB:IMMFF) announced today the results of its Phase 2 clinical study of dapsone for treatment of Alzheimer disease conducted over 52 weeks with 201 patients.
1 out of 7 HIV+ Patients Receiving Dapsone Therapy at Significant Health Risk Due to Dangerously High Levels of Methemoglobin