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dantrolene

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dantrolene /dan·tro·lene/ (dan´tro-lēn) a skeletal muscle relaxant, used as the sodium salt in the treatment of chronic spasticity and the treatment and prophylaxis of malignant hyperthermia.
dantrolene [dan´tro-lēn]
a skeletal muscle relaxant producing its effect primarily on the myoneural junction and the muscle tissue, and only secondarily on the central nervous system. It is used as the sodium salt, administered orally as an antispasmodic in conditions such as stroke, multiple sclerosis, and cerebral palsy; it is also used orally or intravenously in the prophylaxis and treatment of malignant hyperthermia.
dantrolene
skeletal muscle relaxant producing its effect primarily on the neuromuscular junction and the muscle tissue, and only secondarily on the central nervous system.
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Sometimes, centrally acting drugs such as baclofen, tizanidine and diazepam, could be preferred in the muscle contracture of spinal origin, whereas dantrolene sodium, due to its primarily peripheral mechanism of action, may be preferable in spasticity of central origin (stroke and traumatic brain injury) where sensitivity to sedating effects is generally higher'.
Effects of two different doses of eperisone in the treatment of acute ... by Rusinyol, Frandisco Colomer; Perice, Ramon Viladot; Boronat, Enrique Rodriguez; Bosch, Francisco Fer / Journal of Applied Research
Gelbard, however, cautions that dantrolene has side effects and thus may not be appropriate for use in people.
Toehold behind HIV's brain assault identified by Asian News International
By the behavioral assays of beam walking and footprint, we found that dantrolene significantly improved the performance of SCA3-YAC-84Q mice.
Deranged calcium signaling in SCA3 neurons by Bezprozvanny, Ilya / Generations
 
 
 
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