danazol


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danazol

 [dan´ah-zol]
a synthetic androgen that suppresses the ovarian-pituitary axis by inhibiting the release of gonadotropins from the pituitary gland; administered orally for treatment of endometriosis, fibrocystic disease of the breast, hereditary angioedema, and gynecomastia.

da·na·zol

(dā'nă-zol),
A synthetic steroid used to treat endometriosis, fibrocystic breast disease, and angioedema. Indirectly reduces estrogen production by lowering levels of follicle-stimulating hormone and luteinizing hormone.

danazol

/dan·a·zol/ (dah´nah-zōl) an anterior pituitary suppressant used in the treatment of endometriosis, fibrocystic breast disease, and gynecomastia and the prophylaxis of attacks of hereditary angioedema.

danazol

[dan′əzol]
a synthetic androgen that acts to suppress the output of gonadotropins from the pituitary, suppress ovarian hormone production, and directly block ovarian hormone receptors.
indications It is prescribed in the treatment of endometriosis, fibrocystic breast disease, and hereditary angioedema when alternative hormonal therapy is ineffective, contraindicated, or intolerable.
contraindications Genital bleeding; cardiac, liver, or kidney dysfunction; or known hypersensitivity to this drug prohibits its use. It is not prescribed during pregnancy or lactation.
adverse effects Among the most serious adverse reactions are muscle spasms, nausea, weight gain, acne, edema, oily skin, voice changes, and other androgenic effects.

danazol

Endocrinology A non-virilizing anabolic androgen used to manage HANE, fibrocystic breast disease, endometriosis, and possibly autoimmune hemolytic anemia and autoimmune thrombocytopenia, but may mediate immune thrombocytopenia Adverse effects Weight gain, edema, acne, hirsutism, deepening of voice, clitorimegaly, menometrorrhagia, ↓ HDL-C, ↑ liver enzymes, peliosis hepatis, benign intracranial HTN. See Hereditary angioneurotic edema.

da·na·zol

(dā'nă-zol)
A synthetic steroid used to treat endometriosis, fibrocystic breast disease, and angioedema. Indirectly reduces estrogen production by lowering levels of follicle-stimulating hormone and luteinizing hormone.

da·na·zol

(dā'nă-zol)
A synthetic steroid used to treat endometriosis, fibrocystic breast disease, and angioedema.

danazol

(dan´əzol´),
n brand name: Danocrine;
drug class: androgen, α-ethinyl testosterone derivative;
action: decreases FSH and LH output;
uses: endometriosis, prevention of hereditary angioedema, fibrocystic breast disease.

danazol

an attenuated androgen that suppresses the ovarian-pituitary axis by inhibiting the release of gonadotropins from the pituitary gland. In animals, it has been used in the treatment of immune-mediated disorders, including anemia and thrombocytopenia.
References in periodicals archive ?
Tedavi dozu tum olgularda klinik yanit goz onune alinarak yuksek dozda (ornegin Danazol 600 mg/gun) baslanip yavasca dusulmeli ya da dusuk dozda baslanarak yavasca arttirilmali ve semptomlari kontrol altinda tutacak en dusuk doz seklinde ayarlanmalidir, laboratuvar testlerin dozun ayarlanmasinda herhangi bir yarari yoktur (4,25).
The use of preoperative danazol (an attenuated androgen) and tranexamic acid for short-term prophylaxis has also been described (12).
Fedele and co-workers (46) were the first to compare the clinical effects of gestrinone and danazol, observing a significant decrease of pain-related symptoms (dysmenorrhoea, pelvic pain, deep dyspareunia) in both groups, without any significant difference.
DENVER -- Daily self-administered vaginal danazol effectively decreased pain symptoms caused by rectovaginal endometriosis that persisted despite insertion of a levonorgestrel-releasing IUD, a small, prospective, self-controlled pilot study has shown.
Until recently, routine prophylaxis in the United States has been limited primarily to the use of attenuated (synthetic, 17-[alpha]-alkylated) androgens such as danazol, stanozolol, and oxandrolone, which have been shown to increase C1-INH and C4 concentrations, although the exact mode of action of these agents in HAE is not well understood.
Danazol is a synthetic testosterone which binds to progesterone and androgen receptors.
Gonadotropin-releasing hormone agonists (Lai and Huang 2006), danazol (Tamaoka et al.
Vaginal oestrogens, progesterone/progestins and danazol are currently used to obtain local (vagina and urethra), regional (uterus, pelvic structures) and systemic effects or contraception.
In the other trial, CHM was more effective than the hormonal drug danazol, and also resulted in fewer side effects.
The conventional medical treatment approach to endometriosis typically begins with estrogen supression through medications such as Danazol and Lupron.
Synthetic androgens such as danazol are effective in short- and long-term prophylaxis by increasing hepatic production of C1-INH, but have significant side-effects.
You may be offered painkillers, but in severe cases medicine called bromocriptine or Danazol can be effective.