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an agent used as the sodium salt for prevention of pulmonary thromboembolism and deep venous thrombosis in at-risk abdominal surgery patients.


(dal-te-pa-rin) ,


(trade name)


Therapeutic: anticoagulants
Pharmacologic: antithrombotics
Pregnancy Category: B


Prevention of venous thromboembolism (deep vein thrombosis (DVT) and/or pulmonary embolism (PE)) in surgical or medical patients.Extended treatment of symptomatic DVT and/or PE in patients with cancer.Prevention of ischemic complications (with aspirin) in patients with:
  • unstable angina,
  • non–Q-wave MI.


Potentiates the inhibitory effect of antithrombin on Factor Xa and thrombin.

Therapeutic effects

Prevention of thrombus formation.
Decreased incidence of death or recurrent MI.


Absorption: Well absorbed (87%) after administration.
Distribution: Unknown.
Metabolism and Excretion: Unknown.
Half-life: 2.1–2.3 hr.

Time/action profile (antithrombotic effect)

Subcutrapid4 hrup to 24 hr


Contraindicated in: Hypersensitivity to dalteparin, heparin, or pork products; Active major bleeding; Thrombocytopenia related to previous dalteparin therapy.
Use Cautiously in: Patients with severe renal or hepatic impairment; Retinopathy (hypertensive or diabetic); Spinal or epidural anesthesia; Geriatric: Risk of bleeding may be ↑, consider age-related ↓ in renal function and body weight; Obstetric / Lactation / Pediatric: Safety not established; products containing benzyl alcohol should not be used in neonates.
Exercise Extreme Caution in: Spinal/epidural anesthesia or spinal puncture (↑ risk of spinal/epidural hematoma that may lead to long-term or permanent paralysis); Severe uncontrolled hypertension; Bacterial endocarditis, bleeding disorders; GI bleeding/ulceration/pathology; Hemorrhagic stroke; Recent CNS or ophthalmologic surgery; Active GI bleeding/ulceration; History of thrombocytopenia related to heparin.

Adverse Reactions/Side Effects

Central nervous system

  • dizziness


  • reversible ↑ in liver enzymes


  • bleeding
  • thrombocytopenia


Drug-Drug interaction

Risk of bleeding ↑ by concurrent use of thrombolytics, anticoagulants, or agents that affect platelet function including NSAIDS, ticlopidine, clopidogrel, tirofiban, or eptifibatide.


DVT Prophylaxis

Subcutaneous (Adults) Abdominal surgery—2500 IU 1–2 hr before surgery, then once daily for 5–10 days; High-risk patients undergoing abdominal surgery—5000 IU evening before surgery, then once daily for 5–10 days or 2500 IU 1–2 hr before surgery, another 2500 IU 12 hour later, then 5000 IU daily for 5–10 days; Hip replacement surgery—2500 IU within 2 hr before surgery, another 2500 IU evening of the day of surgery ≥6 hr after first dose, then 5000 IU daily for 5–10 days (if surgery is in the evening omit second dose day of surgery) or 5000 IU evening before surgery, then 5000 IU daily for 5–10 days.Medical patients with severely restricted mobility: 5000 IU for 12 to 14 days.

Extended Treatment of Symptomatic VTE in Patients with Cancer

Subcutaneous (Adults) 200 IU/kg once daily (not to exceed 18,000 IU/day) for first 30 days, then 150 IU/kg once daily (not to exceed 18,000 IU/day) for months 2–6.

Angina/Non–Q-wave MI

Subcutaneous (Adults) 120 IU/kg (not to exceed 10,000 IU) q 12 hr with concurrent aspirin.

Renal Impairment

Subcutaneous (Adults) Cancer patients receiving extended treatment of symptomatic VTE with CCr <30 mL/min—Monitor anti-Xa levels (target 0.5–1.5 IU/mL).


Solution for injection (prefilled syringes): 2500 IU/0.2 mL, 5000 IU/0.2 mL, 7500 IU/0.3 mL, 10,000 IU/mL, 12,500 IU/0.5 mL, 15,000 IU/0.6 mL, 18,000 IU/0.72 mL
Solution for injection (multidose vials): 25,000 IU/mL in 3.8–mL vials

Nursing implications

Nursing assessment

  • Assess for signs of bleeding and hemorrhage (bleeding gums; nosebleed; unusual bruising; black, tarry stool; hematuria; fall in hematocrit or BP; guaiac-positive stools). Notify health care professional if these occur.
  • Subcutaneous: Observe injection sites for hematoma, ecchymosis, or inflammation.
  • Lab Test Considerations: Monitor CBC, platelet count, and stools for occult blood periodically during therapy. If thrombocytopenia occurs, monitor closely. If hematocrit ↓ unexpectedly, assess patient for potential bleeding sites.
    • Special monitoring of clotting times (aPTT) is not necessary.
    • May cause asymptomatic ↑ in transaminase levels (AST, ALT).

Potential Nursing Diagnoses

Ineffective tissue perfusion (Indications)
Risk for injury (Side Effects)


  • First dose is administered 1–2 hr before surgery.
    • Dalteparin cannot be used interchangeably (unit for unit) with unfractionated heparin or other low-molecular-weight heparins.
  • Subcutaneous: Administer deep subcut while patient is sitting or lying down. Dalteparin may be injected into the abdominal wall inferior and lateral to the umbilicus, the upper outer side of the thigh, or the upper outer quadrant of the buttock. Rotate injection sites daily. Inject entire length of needle at a 45° or 90° angle while lifting and holding skin between thumb and forefinger.
    • Do not administer IM.
  • Syringe Incompatibility: Do not mix with other injections or infusions.

Patient/Family Teaching

  • Advise patient to report any symptoms of unusual bleeding or bruising, dizziness, itching, rash, fever, swelling, or difficulty breathing to health care professional immediately.
  • Instruct patient not to take aspirin or NSAIDs without consulting health care professional while on dalteparin therapy.

Evaluation/Desired Outcomes

  • Prevention of deep vein thrombosis and pulmonary embolism.
  • Prevention of ischemic complications (with aspirin) in patients with unstable angina or non-Q-wave MI.
  • Reduction of recurrence of VTE in patients with cancer.


/dal·tep·a·rin/ (dal-tep´ah-rin) an antithrombotic used as the sodium salt in the prevention of pulmonary thromboembolism and deep venous thrombosis in at-risk abdominal surgery patients.
References in periodicals archive ?
Treatment of Venous Thromboembolism in Cancer Patients with Dalteparin for up to 12 Months: the DALTECAN Study.
Other well-studied LMWHs include dalteparin and tinzaparin.
Preoperatively, the patient was assessed by Blood Conservation Service (Winnipeg Regional Health Authority) and given Eprex (Janssen, epoetin alfa) and Fragmin (Eisai, dalteparin sodium injection) to optimize hemoglobin and minimize emboli risk, respectively.
Randomized, placebo-controlled trial of dalteparin for the prevention of venous thromboembolism in acutely ill medical patients.
Low-molecular weight heparins (LMWHs), such as enoxaparin, dalteparin and nadroparin, are preferred over heparin in most clinical settings as they can be injected subcutaneously, do not need monitoring and can be administered less frequently.
To examine this possibility, we screened multiple batches of hospital pharmacy-grade heparin for the presence of HEV, including batches of dalteparin sodium that were in use at the hospital when the patient received treatment for appendicitis.
On the first postoperative day, all patients were commenced on a daily dose of 5,000 units of subcutaneous dalteparin sodium.
55) used dalteparin sodium (low molecular weight heparin) 5000 U SC bid during 12 weeks in 12 active UC cases resistant to steroid.
The mean total cost was $3,383 US dollars (95% CI= $2,683$4,083) for dalteparin and $4,952 US dollars (95% CI=$4,718-$5,185) for UFH for inpatient care.
Ozgecmis sorgulamasinda Hemofili C hastasi oldugu ve Trombofili (heterozigot Faktor V Leiden ve homozigot MTHFR) nedeniyle gebelik surecinde ve takibinde toplam 10 ay dalteparin sodyum 5000IU/gun, folik asid 5mg/gun kullandigi ogrenildi.
Her medical history was notable for obstructive sleep apnoea requiring continuous positive airway pressure and an elevated factor VIII level treated with subcutaneous dalteparin 5000 U/day.
Randomized Placebo-Controlled Trial of Dalteparin for the Prevention of Venous Thromboembolism in Acutely Ill Medical Patients.