dactinomycin


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Related to dactinomycin: Daunorubicin, doxorubicin

dactinomycin

 [dak″tĭ-no-mi´sin]
an antitumor antibiotic of the actinomycin complex (actinomycin D), produced by Streptomyces parvulus. Used to treat rhabdomyosarcoma and Wilms' tumor in children, as well as Ewing's sarcoma, Kaposi's sarcoma, osteogenic sarcoma, soft tissue sarcomas, testicular carcinoma, and choriocarcinoma.

dac·ti·no·my·cin

(dak'ti-nō-mī'sin),
An antineoplastic antibiotic produced by several species of Streptomyces (for example, S. parvulus).
See also: actinomycins.
Synonym(s): actinomycin D

dactinomycin

/dac·ti·no·my·cin/ (dak″tĭ-no-mi´sin) actinomycin D, an antibiotic derived from several species of Streptomyces; used as an antineoplastic.

dactinomycin

(dăk′tə-nō-mī′sĭn)
n.
An antibiotic of the actinomycin group, C62H86N12O16, isolated from bacteria and used as an antineoplastic agent in the treatment of certain cancers. Also called actinomycin D.

dactinomycin

[dak′tinōmī′sin]
an antibiotic used as an antineoplastic agent.
indications It is prescribed in the treatment of a variety of malignant neoplastic diseases, including testicular cancer, melanoma, Wilms' tumor, and rhabdomyosarcoma.
contraindications Herpes zoster infection, chickenpox, or known hypersensitivity to this drug prohibits its use.
adverse effects Among the more serious adverse reactions are bone marrow depression, severe GI disturbances, proctitis, alopecia, and ulcers of the mouth.

Actinomycin D

A relatively toxic antibiotic produced by Streptomyces spp, which is used as a chemotherapeutic.
Mechanism Inhibits DNA transcription by RNA polymerase.
Indications Rhabdomyosarcoma, Wilms’ tumour, gestational trophoblastic tumour 
Adverse effects Anorexia, nausea, vomiting, myelosuppression with pancytopenia, diarrhoea

dactinomycin

Oncology An antitumor antibiotic member of a class of drugs first isolated from Streptomyces, and used to treat Wilms' tumor, Ewing sarcoma, embryonal rhabdomyosarcoma, choriocarcinoma, seminoma, KS, lymphoma

dac·ti·no·my·cin

(dak'ti-nō-mī'sin)
An antineoplastic antibiotic produced by several species of Streptomyces (e.g., S. parvulus).

dactinomycin

A cytotoxic drug used to treat cancers mainly of children. Dactinomycin is an antibiotic derived from Streptomyces pavullus which causes breaks in DNA. This side effect renders it unsuitable as an antibacterial drug, but makes it useful as an anti-cancer drug. A brand name is Cosmegen Lyovac. There are other actinomycins in the group produced by Streptomyces chrysomallas .

dac·ti·no·my·cin

(dak'ti-nō-mī'sin)
An antineoplastic antibiotic produced by several species of Streptomyces (e.g., S. parvulus).

dactinomycin

an antibiotic of the actinomycin complex (actinomycin D), produced by several species of Streptomyces; used as an antineoplastic agent.
References in periodicals archive ?
Efforts are made to reduce these chemotherapy-induced complications by ensuring age-dependent doses of dactinomycin and cyclophosphamide, especially in patients <36 months of age.
Dactinomycin is indicated as a single agent, or as part of a combination chemotherapy regimen, for the treatment of gestational trophoblastic neoplasia.
Toremifene CYP3A4 Active Induction: [up arrow] efficacy Inhibition: [up arrow] risk of adverse effects Glucocorticoids CYP3A4 Inhibitors: CYP3A4 inducer [up arrow] risk corticosteroid -related toxicity Inducers: [down arrow] efficacy Reduces efficacy of CYP3A4 substrates Table IV Anticancer drugs that are p-glycoprotein substrates Clilorambucil Etoposide Cisplatin Methylprednisolone Dactinomycin Mitoxantrone Daunorubicin Paclitaxel Dexamethasone Tamoxifen Docetaxel Vinblastine Doxorubicin Vincristine