d-penicillamine


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Related to d-penicillamine: Cuprimine

penicillamine, d-penicillamine

a product of penicillin which chelates copper and other metals; used in the treatment of copper accumulation associated with chronic hepatitis, copper-associated hepatopathy of Bedlington terriers, and lead poisoning.
References in periodicals archive ?
This short course of D-penicillamine avoids the rare side effects of longer-term therapeutic doses of the drug.
For more than modest amounts, alternate day D-penicillamine for 30 to 60 days with supplemental calcium, magnesium, and zinc on the other days to replace these minerals, which penicillamine will chelate along with the other divalent (double-charged) heavy metals.
D-penicillamine provocation showed the magnesium deficit had been corrected and that lead and arsenic were no longer detectable although increase in cadmium excretion was observed and detoxification continued for another six months.
Response to treatment is variable but patients may respond to steroids, plaquenil, methotrexate, D-penicillamine, and cimetidine.