D-aminolevulinic acid synthase | definition of d-aminolevulinic acid synthase by Medical dictionary
delta-aminolevulinic acid synthase (redirected from d-aminolevulinic acid synthase)
δ-a·mi·no·lev·u·lin·ic ac·id syn·thase
an enzyme that catalyzes the reaction of succinyl-CoA with glycine to form δ-aminolevulinate, coenzyme A, and CO2. The committed step in porphyrin biosynthesis.
References in periodicals archive
Decreased PBGD activity can reduce the conversion of porphobilinogen (PBG) into hydroxymethylbilane, which in turn attenuates the feedback inhibition and increases the activity of d-aminolevulinic acid synthase
(d-ALAS), thus increasing the levels of ALA and PBG and consequently urinary excretion thereof.