cytotoxicity, antibody-dependent cell-mediated


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cytotoxicity, antibody-dependent cell-mediated

(sī″tō-tŏk-sĭs′ĭ-tē),

ADCC

The increased ability of natural killer (NK) cells and eosinophils to bind with foreign antigens coated with IgG antibodies and destroy them. When receptors on NK cells bind to the antibody’s Fc fragment, they are stimulated to produce interferon gamma and degranulate, releasing destructive enzymes that kill cells infected with a virus. The presence of antibodies differentiates ADCC from T-cell cytotoxicity, which does not require their presence.