cytotoxicity


Also found in: Dictionary, Thesaurus, Encyclopedia, Wikipedia.

cytotoxicity

 [si″to-tok-sis´ĭ-te]
1. the degree to which an agent has specific destructive action on certain cells.
2. the possession of such destructive action, particularly in reference to lysis of cells by immune phenomena and to antineoplastic agents that selectively kill dividing cells. adj., adj cytotox´ic.
antibody-dependent cell-mediated cytotoxicity (ADCC) (antibody-dependent cellular cytotoxicity) lysis of target cells coated with antibody by effector cells with cytolytic activity and specific immunoglobulin receptors called Fc receptors, including K cells, macrophages, and granulocytes. Lysis of the target cell is extracellular, requires direct cell-to-cell contact, and does not involve complement.
cell-mediated cytotoxicity destruction of a target cell by specific lymphocytes, such as cytotoxic T lymphocytes or NK cells; it may be antibody-dependent (see antibody-dependent cell-mediated c.) or independent, as in certain cell-mediated hypersensitivity reactions.

cy·to·tox·ic·i·ty

(sī'tō-tok-sis'i-tē),
The quality or state of being cytotoxic.

cytotoxicity

/cy·to·tox·ic·i·ty/ (si″to-tok-sis´ĭ-te) the degree to which an agent possesses a specific destructive action on certain cells or the possession of such action.cy´totoxic
antibody-dependent cell-mediated cytotoxicity  (ADCC) lysis of antibody-coated target cells by effector cells with cytolytic activity and Fc receptors.
cell-mediated cytotoxicity  cytolysis of a target cell by effector lymphocytes, such as cytotoxic T lymphocytes or NK cells; it may be antibody-dependent or independent.

cy·to·tox·ic·i·ty

(sī'tō-tok-sis'i-tē)
The quality or state of being cytotoxic.

cytotoxicity

The property of being able to cause damage to, or death of, cells.

cy·to·tox·ic·i·ty

(sī'tō-tok-sis'i-tē)
The qual-ity or state of being cytotoxic.

cytotoxicity (sī´tōtoksis´itē),

n a description of the extent of the destructive or killing capacity of an agent. Most often used to describe the character of immune activity or toxicity of certain drugs that limit the development of cancer cells.

cytotoxicity

destruction of cells; used to describe lysis of cells by immune mechanisms. See also antibody-dependent cell-mediated cytotoxicity (ADCC).
References in periodicals archive ?
The cytotoxicity of the five alkaloids (1-5) was determined by the resazurin assays and the obtained [ICS.
Cytotoxicity and cellular uptake of beta-lactoglobulin nanoparticles: Quantitative studies
This study is also very similar to our method of study in that the methanol and aqueous extracts of the samples which were investigated in cytotoxicity way revealed that among the samples, Anabaena ISC 90 and Anabaena ISC 55 samples of the methanol extract and Anabaena 88 sample of the aqueous extract had a greater impact on HeLa cell lines.
Rapid colorimetric assay for cellular growth and survival: Application to Proliferation and cytotoxicity assays'.
The cytotoxicity kits are used by major pharmaceutical, chemical and cosmetic industries, contract service labs as well as authorities analysing environmental toxicants.
Keywords: cytotoxicity, cell modelling, dynamic modelling, parameter estimation, system identification
Monitoring brevetoxins during a Gymnodinium breve red tide: comparison of sodium channel specific cytotoxicity assay and mouse bioassay for determination of neurotoxic shellfish toxins in shell-fish extracts.
Additionally, these Parylenes have been subjected to an array of ISO-10993 biological evaluations, including acute systemic toxicity, intracutaneous reactivity, cytotoxicity, sensitization, hemocompatibility and implantation (2, 12 and 26 weeks).
ConverseLy, participants with longer periods of weight stability appeared to have higher NK cytotoxicity and thus stronger immune systems.
Both the bottle and HDPE closure material meet current biological testing standards, including USP Class VI, USP, European Pharmacopoeia for Abnormal Toxicity, Cytotoxicity, Hemolysis and are Non-pyrogenic.
The endogenous production of ozone may contribute to cytotoxicity, lipid loading in macrophages, and deformation of apolipoproteins, they added.