cytotoxicity


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cytotoxicity

 [si″to-tok-sis´ĭ-te]
1. the degree to which an agent has specific destructive action on certain cells.
2. the possession of such destructive action, particularly in reference to lysis of cells by immune phenomena and to antineoplastic agents that selectively kill dividing cells. adj., adj cytotox´ic.
antibody-dependent cell-mediated cytotoxicity (ADCC) (antibody-dependent cellular cytotoxicity) lysis of target cells coated with antibody by effector cells with cytolytic activity and specific immunoglobulin receptors called Fc receptors, including K cells, macrophages, and granulocytes. Lysis of the target cell is extracellular, requires direct cell-to-cell contact, and does not involve complement.
cell-mediated cytotoxicity destruction of a target cell by specific lymphocytes, such as cytotoxic T lymphocytes or NK cells; it may be antibody-dependent (see antibody-dependent cell-mediated c.) or independent, as in certain cell-mediated hypersensitivity reactions.

cy·to·tox·ic·i·ty

(sī'tō-tok-sis'i-tē),
The quality or state of being cytotoxic.

cytotoxicity

/cy·to·tox·ic·i·ty/ (si″to-tok-sis´ĭ-te) the degree to which an agent possesses a specific destructive action on certain cells or the possession of such action.cy´totoxic
antibody-dependent cell-mediated cytotoxicity  (ADCC) lysis of antibody-coated target cells by effector cells with cytolytic activity and Fc receptors.
cell-mediated cytotoxicity  cytolysis of a target cell by effector lymphocytes, such as cytotoxic T lymphocytes or NK cells; it may be antibody-dependent or independent.

cy·to·tox·ic·i·ty

(sī'tō-tok-sis'i-tē)
The quality or state of being cytotoxic.

cytotoxicity

The property of being able to cause damage to, or death of, cells.

cy·to·tox·ic·i·ty

(sī'tō-tok-sis'i-tē)
The qual-ity or state of being cytotoxic.

cytotoxicity (sī´tōtoksis´itē),

n a description of the extent of the destructive or killing capacity of an agent. Most often used to describe the character of immune activity or toxicity of certain drugs that limit the development of cancer cells.

cytotoxicity

destruction of cells; used to describe lysis of cells by immune mechanisms. See also antibody-dependent cell-mediated cytotoxicity (ADCC).
References in periodicals archive ?
The synthesized compounds were evaluated for their hemolytic activity to ascertain their cytotoxicity profile.
In addition, the cytotoxicity assay was performed using MTT to assess the metabolically active cells which convert the dye to a water-insoluble dark blue formazan by reduction process of splitting tetrazolium ring (Alvarez et al.
Though they displayed lower cytotoxicity towards carcinoma cells compared to leukemia cell lines, collateral sensitivity of resistant phenotypes to compounds 1, 2, 3, 4 and 6 as compared to their respective sensitive counterparts was also observed in many cases.
tuberculosis belonging to different strain families induce different levels of cytotoxicity in human alveolar epithelial cells (A549) in vitro.
Cytotoxicity and cellular uptake of beta-lactoglobulin nanoparticles: Quantitative studies
The cytotoxicity and genotoxicity evaluation has been subject of researches among scientists in order to elucidate the Zn concentrations capable of inducing cellular damage in different tissues.
Biocompatibility and cytotoxicity of two novel low-shrinkage dental resin matrices.
Materials and manufacture of specimens For the evaluation of cytotoxicity of glass-ionomer cements on UMR-106 osteoblast-like cells and NIH3T3 mouse fibroblast cells, six glass-ionomer cements divided in two groups were used.
Hence, cytotoxicity is not a matter of concern for the proposed nanostructures," Dr.
9) Also, the extracts used in this study were undiluted at day 1, since a pilot study demonstrated that cytotoxicity increased concomitantly with extract concentration (data not shown).
The extract displayed dose dependent and cell specific antiproliferative cytotoxicity against the cell lines tested.
They measured and compared the cytotoxicity induced by arsenicals and their metabolic profiles in vitro.