cytotoxic drugs


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cytotoxic drugs

Drugs capable of damaging or killing cells. These can be used in the treatment of cancer because their effect is greatest on cells which are reproducing most rapidly. The cytotoxic drugs include alkylating agents, such as cyclophosphamide, melphalan and chlorambucil, that interfere with cell growth differentiation and function; cytotoxic antibiotics, such as dactinomycin, daunorubicin and doxorubicin, that bind to DNA blocking its transcription; antimetabolites, such as fluoruracil, cytarabine and mercaptopurine, that interfere with the action of folates; vinca alkaloids, such as vinblastine, vincristine and taxol, that block mitosis; and the TOPOISOMERASE 1 inhibitors, such as etoposide, anthracyclines and anthrapyrazoles, that interfere with nuclear enzymes required for DNA replication and the separation of daughter chromosomes.

Cytotoxic drugs

Drugs that function by destroying cells.
Mentioned in: Antirheumatic Drugs

cytotoxic drugs

agents with anticancer properties that may also damage normal cells

cytotoxic

having a deleterious effect upon cells.

cytotoxic antibody
see cytotoxic antibody.
cytotoxic drugs
generally refers to those used in chemotherapy of neoplasms, e.g. cyclophosphamide, vincristine, etc.
cytotoxic T lymphocyte
see T lymphocyte.
References in periodicals archive ?
XR9576 has also successfully completed further Phase IIa combination studies with the cytotoxic drugs doxorubicin and paclitaxel.
This research is targeted towards pharma companies and CMOs working in the field of HPAPIs and cytotoxic drugs.
Due to the special containment requirements for manufacturing highly potent active pharmaceutical ingredients and cytotoxic drugs, we have seen many Contract Manufacturing Organizations (CMO's) invest in building additional capacity in this area.
The problem with cytotoxic drugs is they are also dangerous, and can damage healthy cells.
In preclinical studies, OGX-427 has shown to significantly reduce levels of Hsp27, induce apoptosis in several cancer cell lines, has single agent anti-tumour activity, and acts as a chemosensitizer with several cytotoxic drugs, including docetaxel.
the cytotoxic drugs used in cancer treatment and their metabolites).
Of particular interest to us, and emphasized in the patent, is the use of a B-cell specific antibody, such as our CD22 humanized antibody, for the therapy of non-Hodgkin's lymphoma, whereby a site-specific conjugation of cytotoxic drugs could be made with this antibody that internalizes into B-cells," she added.
Thus, when a tumour is detected the disease may already have begun to spread to other tissue sites (metastasis), in which case recourse often must be made to treatment by systemically administered cytotoxic drugs.
For caregivers and their patients, the therapeutic area that is at the forefront of attempts to mitigate exposure to cytotoxic drugs is clinical oncology, a field that - in spite of promising new drugs based on therapeutic antibodies - continues to rely heavily on antineoplastics, a class that includes alkylating agents and antimetabolites, to treat a wide range of cancers.
As has been demonstrated in this study, pretargeting with bsMAb can also be employed to improve the selective delivery of therapeutic isotopes, as well as cytotoxic drugs, to cancers.
New guidelines for the management of cytotoxic drugs and their occupational risks have been released by WorkCover after an extensive and lengthy review.
The final chapters focus on blood transfusion, parenteral nutrition, pediatric IVs, and administration of cytotoxic drugs.

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