cytotoxic T-lymphocyte antigen-4

cytotoxic T-lymphocyte antigen-4 (CTLA-4),

expressed by activated T cells. When synthesized as a soluble molecule fused to the Fc of IgG, it is used as a biologic therapy in rhematic diseases, because it blocks a costimulatory molecule on B lymphocytes.
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According to the company, AGEN1884 is an immune checkpoint modulator (CPM) antibody that binds to cytotoxic T-lymphocyte antigen-4 (CTLA-4).
Promising clinical data from studies employing monoclonal antibodies that bind to checkpoint molecules, such as cytotoxic T-lymphocyte antigen-4 (CTLA-4) and programmed death receptor-1 (PD-1), have generated considerable excitement in the field of cancer immunotherapy, concluded the company.
Cytotoxic T-lymphocyte antigen-4 (CTLA-4): a negative feedback mechanism that limits the body's developing immune response to keep it from becoming overactivated and causing nonspecific damage

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