Cytotoxic T-lymphocyte antigen-4 | definition of cytotoxic T-lymphocyte antigen-4 by Medical dictionary
cytotoxic T-lymphocyte antigen-4
cytotoxic T-lymphocyte antigen-4 (CTLA-4),
expressed by activated T cells. When synthesized as a soluble molecule fused to the Fc of IgG, it is used as a biologic therapy in rhematic diseases, because it blocks a costimulatory molecule on B lymphocytes.
References in periodicals archive
Cytotoxic T-lymphocyte antigen-4
(CTLA-4): a negative feedback mechanism that limits the body's developing immune response to keep it from becoming overactivated and causing nonspecific damage